Nonlinear waves of electrical excitation initiate cardiac contraction. Abnormal wave propagation in the heart, e.g., spiral waves, can lead to sudden cardiac arrest. This study analyzed the dynamics of spiral waves under the influence of an instability called negative filament tension, and examined how the spiral waves can be eliminated through high-frequency pacing. A generic anatomical model of the left ventricle of the human heart and the Aliev–Panfilov model for cardiac tissue were used. The study showed that the source of such arrhythmia is elongated filaments with lengths that can be 10–20 times greater than the characteristic thickness of the heart wall. In anisotropic tissue, the filament elongated before it was annihilated at the base of the heart. The spiral waves were eliminated through overdrive pacing with stimulation periods from 0.8 to 0.95 relative to the spiral wave period. The minimum time for the expulsion was about 10 s.

中文翻译：

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人心脏左心室模型中具有负丝张力的涡旋波及其超速起搏

非线性电激发波启动心脏收缩。心脏中的异常波传播，例如螺旋波，可导致心脏骤停。这项研究分析了在称为负丝张力的不稳定性影响下螺旋波的动力学，并研究了如何通过高频起搏消除螺旋波。使用了人类心脏左心室的通用解剖模型和心脏组织的 Aliev-Panfilov 模型。研究表明，这种心律失常的根源是细长的细丝，其长度可能是心脏壁特征厚度的 10-20 倍。在各向异性组织中，细丝在它在心脏底部消失之前被拉长。螺旋波通过超速起搏消除，刺激周期从 0 开始。8 到 0.95 相对于螺旋波周期。驱逐的最短时间约为 10 秒。