Homocysteine (Hcy) is considered to be a risk factor for cardiovascular and cerebrovascular diseases. Few studies have evaluated the distribution of Hcy on a large-scale health examination. Accordingly, this study aimed to investigate the level and distribution of Hcy in the population with healthy physical examination and the correlation with other biomarkers, and analyzed for cardiovascular and other diseases. Measurements of serum Hcy, TC, TG, LDL-c, HDL-c, ALT, ALP, γ-GT, TBIL, GLU, urea, Cr, UA, and related metabolic risk factors were selected for analysis from 8063 medical examination samples collected from February 2017 to April 2020. The relationship between Hcy and other biochemical indicators were evaluated with the multivariate regression model of age, gender, smoking, drinking, body mass index (BMI), systolic blood pressure (SBP), and diastolic blood pressure (DBP). Among 8063 cases, the age, BMI, SBP, and DBP of the high-Hcy group were higher than those of the low-Hcy group, the difference was statistically significant (P < 0.001), and the proportion of males, smoking, and drinking were higher than the low-Hcy group, the difference was statistically significant (P < 0.001); Hcy of the abnormal GLU group is higher than the normal GLU group (P = 0.002) and the Hcy of abnormal TG and HDL is higher than that of the normal blood lipid group (P < 0.001); Hcy of people with abnormal UA and Urea was higher than that of people with normal renal function (P < 0.001, P = 0.007). In multivariate analysis, lnHDL-C was negatively correlated with lnHcy (β = − 0.038, SE = 0.016, P = 0.019), lnCr was positively correlated with lnHcy (β = 0.055, SE = 0.016, P < 0.001), lnUA and lnHcy were positive correlated (β = 0.043, SE = 0.019, P = 0.022). Hcy is closely related to HDL-c, Cr, and UA, which indicates that Hcy may affect the metabolism of HDL-c and UA, and can also be used as an auxiliary diagnostic index for kidney injury.

中文翻译：

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表观健康人群中同型细胞的分布特征及影响因素

同型半胱氨酸（Hcy）被认为是心脑血管疾病的危险因素。很少有研究评估 Hcy 在大规模健康检查中的分布。因此，本研究旨在调查健康体检人群中Hcy的水平和分布以及与其他生物标志物的相关性，并对心血管和其他疾病进行分析。从采集的8063份体检样本中选取血清Hcy、TC、TG、LDL-c、HDL-c、ALT、ALP、γ-GT、TBIL、GLU、尿素、Cr、UA及相关代谢危险因素的测定进行分析2017年2月至2020年4月。采用年龄、性别、吸烟、饮酒、体重指数（BMI）、收缩压（SBP）、和舒张压 (DBP)。8063例患者中，高Hcy组的年龄、BMI、SBP、DBP均高于低Hcy组，差异有统计学意义（P<0.001），男性、吸烟、饮酒高于低Hcy组，差异有统计学意义（P < 0.001）；GLU异常组Hcy高于正常GLU组（P=0.002），TG、HDL异常组Hcy高于血脂正常组（P<0.001）；UA和尿素异常者Hcy高于肾功能正常者（P < 0.001，P = 0.007）。多变量分析中，lnHDL-C与lnHcy呈负相关（β=-0.038，SE=0.016，P=0.019），lnCr与lnHcy呈正相关（β=0.055，SE=0.016，P<0.001），lnUA 和 lnHcy 呈正相关（β = 0.043，SE = 0.019，P = 0.022）。Hcy与HDL-c、Cr、UA密切相关，说明Hcy可能影响HDL-c和UA的代谢，也可作为肾损伤的辅助诊断指标。