Abstract

Chemical investigation of the whole plant of Sauropus hirsutus Beille led to the isolation of eight quinolines and two known flavonoids. Furthermore, five quinolines were new, two were reported in plant for the first time and one was known. Cytotoxicity evaluation against cholangiocarcinoma, KKU-M156, showed that the most active compound was 4-hydroxy-6-methoxy-7,8-methylenedioxyquinaldine (IC₅₀ 20.54 ± 6.82 µM) which was a little more active than the cisplatin standard (IC₅₀ 24.39 ± 1.14 µM).

中文翻译：

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多毛蜥的五种新喹啉生物碱及其细胞毒性

摘要

对Sauropus hirsutus Beille整株植物的化学研究导致分离出八种喹啉和两种已知的类黄酮。其中5种喹啉为新化合物，2种为首次在植物中报道，1种为已知化合物。对胆管癌 KKU-M156 的细胞毒性评估表明，最具活性的化合物是 4-hydroxy-6-methoxy-7,8-methylenedioxyquinaldine (IC ₅₀ 20.54 ± 6.82 µM)，它比顺铂标准品 (IC ₅₀ 24.39 ± 1.14 µM）。