Modular Design of Supramolecular Ionic Peptides with Cell-Selective Membrane Activity,ChemBioChem

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Modular Design of Supramolecular Ionic Peptides with Cell-Selective Membrane Activity
ChemBioChem ( IF 2.6 ) Pub Date : 2021-09-10 , DOI: 10.1002/cbic.202100323
Su Yang ₁ , Yan Chang ₂ , Shan Hazoor ₁ , Chad Brautigam ₃ , Frank W Foss ₁ , Zui Pan ₂ , He Dong ₁

Affiliation

Molecularly designed cationic peptides having low membrane activity undergo cell-specific enzyme triggered chemical transformation and self-assembly to form supramolecular cationic clusters with enhanced membrane activity. The cell-selective membrane activity by in situ formed peptide assembly is a highly desirable feature for targeted molecular imaging and therapy.