Osteoporosis is a common metabolic bone disorder typically characterized by decreased bone mass and an increased risk of fracture. At present, the detailed molecular mechanism underlying the development of osteoporosis remains to be elucidated. Accumulating evidence shows that non‑coding (nc)RNAs, such as microRNAs (miRNAs), long ncRNAs (lncRNAs) and circular RNAs (circRNAs), play significant roles in osteoporosis through the post‑transcriptional regulation of gene expression as regulatory factors. Previous studies have demonstrated that ncRNAs participate in maintaining bone homeostasis by regulating physiological and developmental processes in osteoblasts, osteoclasts and bone marrow stromal cells. In the present review, the latest research investigating the involvement of miRNAs, lncRNAs and circRNAs in regulating the differentiation, proliferation, apoptosis and autophagy of cells that maintain the bone microenvironment in osteoporosis is summarized. Deeper insight into the aspects of osteoporosis pathogenesis involving the deregulation of ncRNAs could facilitate the development of therapeutic approaches for osteoporosis.

中文翻译：

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miRNA、lncRNA 和 circRNA 作为骨稳态调节因子对骨质疏松症的影响（综述）。

骨质疏松症是一种常见的代谢性骨病，通常以骨量减少和骨折风险增加为特征。目前，骨质疏松症发展的详细分子机制仍有待阐明。越来越多的证据表明，非编码 (nc) RNA，例如 microRNA (miRNA)、长 ncRNA (lncRNA) 和环状 RNA (circRNA)，通过作为调节因子对基因表达的转录后调节在骨质疏松症中发挥重要作用。先前的研究表明，ncRNA 通过调节成骨细胞、破骨细胞和骨髓基质细胞的生理和发育过程参与维持骨稳态。在本综述中，最新研究调查了 miRNA、lncRNA 和 circRNA 参与调节分化，总结了骨质疏松症中维持骨微环境的细胞的增殖、凋亡和自噬。更深入地了解涉及 ncRNA 失调的骨质疏松症发病机制的各个方面可以促进骨质疏松症治疗方法的发展。