We have been studying inflammatory diseases, with a special focus on IL-6, and discovered two concepts related to inflammation development. One is the gateway reflex, which is induced by the activation of specific neural circuits followed by establishing gateways for autoreactive CD4+ T cells to pass through blood barriers toward the central nervous system (CNS) and retina during tissue-specific inflammatory diseases. We found that the formation of these gateways is dependent on the IL-6 amplifier, which is machinery for enhanced NF-κB activation in endothelial cells at specific sites. We have found five gateway reflexes in total. Here, we introduce the gateway reflex and the IL-6 amplifier.

中文翻译：

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网关反射：突破血液屏障。

我们一直在研究炎症性疾病，特别关注 IL-6，并发现了与炎症发展相关的两个概念。一种是网关反射，它是由特定神经回路的激活诱导的，然后在组织特异性炎症性疾病期间为自身反应性 CD4+ T 细胞通过血屏障向中枢神经系统 (CNS) 和视网膜建立网关。我们发现这些通道的形成依赖于 IL-6 放大器，IL-6 放大器是增强特定部位内皮细胞 NF-κB 活化的机制。我们总共发现了五个网关反射。在这里，我们介绍网关反射和 IL-6 放大器。