Several chemical compounds are considered to be promising as adjuvants in the treatment of periodontitis. Antimicrobials, anti-inflammatory drugs or, more recently, pro-regenerative or antioxidant molecules have shown a very interesting potential to improve the outcomes of mechanical biofilm removal and promote the healing of the damaged tissues. However, their clinical effect is often limited by the challenge of achieving effective and prolonged drug delivery within the periodontal lesion, while limiting the risk of toxicity. In-situ forming implants (ISFI) are ‘implantable’ drug-delivery systems that have gained considerable attention over the last few decades due to their multiple biomedical applications. They are liquids that, when injected at the site to be treated, form a semi-solid or solid dosage form that provides safe and locally controlled drug release. This review discusses current data and future prospects for the use of ISFI in periodontal treatment.

几种化合物被认为有希望作为治疗牙周炎的佐剂。抗菌剂、抗炎药或最近的促再生或抗氧化分子已显示出非常有趣的潜力，可以改善机械生物膜去除的结果并促进受损组织的愈合。然而，它们的临床效果通常受到在牙周病变内实现有效和延长药物递送的挑战的限制，同时限制毒性风险。原位成形植入物 (ISFI) 是“可植入的”药物输送系统，由于其多种生物医学应用，在过去几十年中受到了广泛关注。它们是液体，当注射到要治疗的部位时，形成半固体或固体剂型，可提供安全和局部控制的药物释放。本综述讨论了在牙周治疗中使用 ISFI 的当前数据和未来前景。