Several immune cell types (neutrophils, eosinophils, T cells, and innate-like lymphocytes) display coordinated migration patterns when a population, formed of individually responding cells, moves through inflamed or infected tissues. "Swarming" refers to the process in which a population of migrating leukocytes switches from random motility to highly directed chemotaxis to form local cell clusters. Positive feedback amplification underlies this behavior and results from intercellular communication in the immune cell population. We here highlight recent findings on neutrophil swarming from mouse models, zebrafish larvae, and in vitro platforms for human cells, which together advanced our understanding of the principles and molecular mechanisms that shape immune cell swarming.

中文翻译：

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蜂拥免疫细胞群中的正反馈放大。

当由个体响应细胞形成的群体穿过发炎或受感染的组织时，几种免疫细胞类型（中性粒细胞、嗜酸性粒细胞、T 细胞和先天样淋巴细胞）会显示出协调的迁移模式。“蜂拥”是指迁移的白细胞群从随机运动转变为高度定向的趋化性以形成局部细胞簇的过程。正反馈放大是这种行为的基础，是免疫细胞群中细胞间通讯的结果。我们在此重点介绍小鼠模型、斑马鱼幼虫和人体细胞体外平台中中性粒细胞群的最新发现，这些发现共同促进了我们对形成免疫细胞群的原理和分子机制的理解。