Sterilizing Effects of Novel Regimens Containing TB47, Clofazimine and Linezolid in a Murine Model of Tuberculosis,Antimicrobial Agents and Chemotherapy

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Sterilizing Effects of Novel Regimens Containing TB47, Clofazimine and Linezolid in a Murine Model of Tuberculosis
Antimicrobial Agents and Chemotherapy ( IF 4.1 ) Pub Date : 2021-07-19 , DOI: 10.1128/aac.00706-21
Wei Yu _{1,

2,

3} , Buhari Yusuf _{1,

2,

3} , Shuai Wang _{1,

2,

3} , Xirong Tian _{1,

2,

4} , H M Adnan Hameed _{1,

2} , Zhili Lu _{1,

2} , Gift Chiwala _{1,

2,

3} , Md Shah Alam _{1,

2,

3} , Gregory M Cook _{5,

6} , Dmitry A Maslov ₇ , Nanshan Zhong _{2,

8} , Tianyu Zhang _{1,

2,

3}

Affiliation

TB47, a new drug candidate targeting QcrB in the electron transport chain, has shown a unique synergistic activity with clofazimine and formed a highly sterilizing combination. Here, we investigated the sterilizing effects of several all-oral regimens ...

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