Gastrointestinal tumors are common malignant tumors in the digestive tract, of which gastric cancer is the third leading cause of cancer death and colorectal cancer is the fourth most deadly cancer. Nowadays, surgical resection remains to be one of the main measures for treating digestive tract tumors, and gastrointestinal anastomosis remains to be a key step in gastrointestinal surgery. Mg and its alloys have great potentials to be used for gastrointestinal anastomosis as anastomotic nail materials due to their biodegradability, good mechanical properties and biocompatibility. In this study, Mg–2Zn–0.5Nd (ZN20) alloy fine wires showed great potential as surgical staples. When we performed in vitro corrosion experiments, drainage fluid was collected from different parts of the patient's abdominal cavity after surgery for the first time to replace the traditional simulation fluid and to more realistically simulate the microenvironment required by the anastomotic nail. ZN20 alloy has an ultimate tensile strength of 256 MPa, an elongation rate of 12.56%, a tensile force in anastomosis of 16.8 N, and a rupture pressure after anastomosis at 17 kPa, which means that a sufficient mechanical support was provided after anastomosis. The statistical analysis and histopathological analysis of biochemical tests indicate that ZN20 alloy has no adverse effect on the normal metabolism of liver, kidney and body, but has superior biocompatibility and biosafety. This work confirms that ZN20 possesses a great application potential in the clinical field as a new type of gastrointestinal anastomotic nail material.

胃肠道肿瘤是消化道常见的恶性肿瘤，其中胃癌是癌症死亡的第三大原因，结直肠癌是第四大致命癌症。目前，手术切除仍是治疗消化道肿瘤的主要措施之一，而胃肠吻合术仍是消化道手术的关键步骤。镁及其合金由于其可生物降解性、良好的机械性能和生物相容性，在胃肠吻合术中作为吻合钉材料具有很大的潜力。在这项研究中，Mg-2Zn-0.5Nd (ZN20) 合金细丝显示出作为手术钉的巨大潜力。我们在进行体外腐蚀实验时，从患者的不同部位收集了引流液。手术后腹腔首次替代传统模拟液，更真实地模拟吻合钉所需的微环境。ZN20合金的极限抗拉强度为256 MPa，延伸率为12.56%，吻合时拉力为16.8 N，吻合后破裂压力为17 kPa，这意味着吻合后提供了足够的机械支撑。生化试验的统计分析和组织病理学分析表明，ZN20合金对肝、肾和机体的正常代谢无不良影响，但具有优越的生物相容性和生物安全性。这项工作证实了ZN20作为一种新型胃肠吻合钉材料在临床领域具有巨大的应用潜力。