Dosimetry in radiotherapy is extremely important to guarantee effectiveness of the treatment, as described by quality assurance procedures. The main dosimeter framework proposed by International Protocols is commonly based on determinations of in-water absorbed dose. Gel dosimetry, mainly based on liquid water, offers the unique characteristic that the phantom constitutes itself the radiosensitive material. This study reports on the suitability of gel dosimetry formulations, typically implemented for clinical purposes, evaluating dosimetry outputs by means of PENELOPE and FLUKA Monte Carlo simulations, along with experimental data. The effects on the absorbed dose distributions due to variation in the mass density and the mean excitation energy are calculated for BANG®, Fricke, ITABIS, MAGIC, NBT-Pluronic, NIPAM, PAGAT, and PRESAGE formulations at irradiations with 6 and 15 MV photon and 6 MeV electron beams. Dosimetry parameters for photon and electron beams are calculated, and effects due to variations in mass density and mean excitation energy are carefully investigated. According to the results obtained from Monte Carlo simulations, along with dose profile comparisons with simulations of in-water irradiations, and comparisons with experimental data, all studied gel dosimetry formulations are capable of assessing reliable dosimetry outputs extracted from 3D dose distributions, even with uncertainties in their mass density or mean excitation energy of ±10%.

如质量保证程序所述，放射治疗中的剂量测定对于保证治疗的有效性极为重要。国际协议提出的主要剂量计框架通常基于水中吸收剂量的测定。凝胶剂量测定，主要基于液态水，提供了独特的特性，即体模本身就是辐射敏感材料。本研究报告了凝胶剂量学配方的适用性，通常用于临床目的，通过 PENELOPE 和 FLUKA 蒙特卡罗模拟评估剂量学输出，以及实验数据。计算了 BANG®、Fricke、ITABIS、MAGIC、NBT-Pluronic、NIPAM、PAGAT、和 PRESAGE 配方在 6 和 15 MV 光子和 6 MeV 电子束照射下。计算了光子和电子束的剂量学参数，并仔细研究了由于质量密度和平均激发能量的变化而产生的影响。根据蒙特卡罗模拟获得的结果，以及与水中辐照模拟的剂量分布比较，以及与实验数据的比较，所有研究的凝胶剂量学配方都能够评估从 3D 剂量分布中提取的可靠剂量学输出，即使存在不确定性质量密度或平均激发能量为±10%。并且仔细研究了由于质量密度和平均激发能量的变化引起的影响。根据蒙特卡罗模拟获得的结果，以及与水中辐照模拟的剂量分布比较，以及与实验数据的比较，所有研究的凝胶剂量学配方都能够评估从 3D 剂量分布中提取的可靠剂量学输出，即使存在不确定性质量密度或平均激发能量为±10%。并且仔细研究了由于质量密度和平均激发能量的变化引起的影响。根据蒙特卡罗模拟获得的结果，以及与水中辐照模拟的剂量分布比较，以及与实验数据的比较，所有研究的凝胶剂量学配方都能够评估从 3D 剂量分布中提取的可靠剂量学输出，即使存在不确定性质量密度或平均激发能量为±10%。