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Licofelone, a potent COX/5-LOX inhibitor and a novel option for treatment of neurological disorders
ProstaglandIns & Other Lipid Mediators ( IF 2.5 ) Pub Date : 2021-09-10 , DOI: 10.1016/j.prostaglandins.2021.106587
Seyed Mehrad Razavi 1 , Danial Khayatan 1 , Zahra Najafi Arab 1 , Saeideh Momtaz 2 , Kimia Zare 3 , Razieh Mohammad Jafari 4 , Ahmad Reza Dehpour 5 , Amir Hossein Abdolghaffari 6
Affiliation  

Neurological disorders result in disability and morbidity. Neuroinflammation is a key factor involved in progression or resolution of a series of neurological disorders like Huntington disease (HD), Parkinson’s disease (PD), Alzheimer’s disease (AD), Spinal Cord Injury (SCI), and Seizure. Thereby, anti-inflammatory drugs have been developed to improve the neurodegenerative impairments. Licofelone is an approved osteoarthritis drug that inhibits both the COX (cyclooxygenase) and 5-LOX (lipoxygenase) pathways. Licofelone has pain-relieving and anti-inflammatory effects and it was shown to have neuroprotective properties in the central nervous system, which is implicated in its regulatory effect on the COX/5-LOX pathway, inflammatory cytokines, and immune responses. In this study, we briefly review the various features of neurological disorders and the function of COX/LOX in their flare up and current pharmacological products for their management. Moreover, this review attempts to summarize potential therapeutics that target the immune responses within the central nervous system. A better understanding of the interactions between Licofelone and the nervous systems will be crucial to demonstrate the possible efficacy of Licofelone in neurological disorders.



中文翻译:

Licofelone,一种强效 COX/5-LOX 抑制剂和治疗神经系统疾病的新选择

神经系统疾病会导致残疾和发病率。神经炎症是一系列神经系统疾病进展或消退的关键因素,如亨廷顿病 (HD)、帕金森病 (PD)、阿尔茨海默病 (AD)、脊髓损伤 (SCI) 和癫痫发作。因此,已经开发出抗炎药来改善神经退行性损伤。Licofelone 是一种经批准的骨关节炎药物,可抑制 COX(环氧合酶)和 5-LOX(脂氧合酶)途径。Licofelone 具有缓解疼痛和抗炎作用,并显示在中枢神经系统中具有神经保护特性,这与它对 COX/5-LOX 通路、炎性细胞因子和免疫反应的调节作用有关。在这项研究中,我们简要回顾了神经系统疾病的各种特征和 COX/LOX 在其突然发作中的功能以及当前用于其管理的药理学产品。此外,本综述试图总结针对中枢神经系统内免疫反应的潜在治疗方法。更好地了解 Licofelone 和神经系统之间的相互作用对于证明 Licofelone 在神经系统疾病中可能的功效至关重要。

更新日期:2021-09-20
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