Neurological disorders result in disability and morbidity. Neuroinflammation is a key factor involved in progression or resolution of a series of neurological disorders like Huntington disease (HD), Parkinson’s disease (PD), Alzheimer’s disease (AD), Spinal Cord Injury (SCI), and Seizure. Thereby, anti-inflammatory drugs have been developed to improve the neurodegenerative impairments. Licofelone is an approved osteoarthritis drug that inhibits both the COX (cyclooxygenase) and 5-LOX (lipoxygenase) pathways. Licofelone has pain-relieving and anti-inflammatory effects and it was shown to have neuroprotective properties in the central nervous system, which is implicated in its regulatory effect on the COX/5-LOX pathway, inflammatory cytokines, and immune responses. In this study, we briefly review the various features of neurological disorders and the function of COX/LOX in their flare up and current pharmacological products for their management. Moreover, this review attempts to summarize potential therapeutics that target the immune responses within the central nervous system. A better understanding of the interactions between Licofelone and the nervous systems will be crucial to demonstrate the possible efficacy of Licofelone in neurological disorders.

神经系统疾病会导致残疾和发病率。神经炎症是一系列神经系统疾病进展或消退的关键因素，如亨廷顿病 (HD)、帕金森病 (PD)、阿尔茨海默病 (AD)、脊髓损伤 (SCI) 和癫痫发作。因此，已经开发出抗炎药来改善神经退行性损伤。Licofelone 是一种经批准的骨关节炎药物，可抑制 COX（环氧合酶）和 5-LOX（脂氧合酶）途径。Licofelone 具有缓解疼痛和抗炎作用，并显示在中枢神经系统中具有神经保护特性，这与它对 COX/5-LOX 通路、炎性细胞因子和免疫反应的调节作用有关。在这项研究中，我们简要回顾了神经系统疾病的各种特征和 COX/LOX 在其突然发作中的功能以及当前用于其管理的药理学产品。此外，本综述试图总结针对中枢神经系统内免疫反应的潜在治疗方法。更好地了解 Licofelone 和神经系统之间的相互作用对于证明 Licofelone 在神经系统疾病中可能的功效至关重要。