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Preparation and Properties of Hollow Magnetic Liquid Crystal Molecularly Imprinted Polymers as Silybin Sustained-release Carriers
ChemistrySelect ( IF 1.9 ) Pub Date : 2021-09-09 , DOI: 10.1002/slct.202101786 Ni Tan 1 , Can Chen 1 , Kang Ji 1 , Sen Liao 1 , Yaqing Liu 1 , Lin Hu 1 , Leqing He 1 , Zui Ding 1
ChemistrySelect ( IF 1.9 ) Pub Date : 2021-09-09 , DOI: 10.1002/slct.202101786 Ni Tan 1 , Can Chen 1 , Kang Ji 1 , Sen Liao 1 , Yaqing Liu 1 , Lin Hu 1 , Leqing He 1 , Zui Ding 1
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In this work, a new drug carrier, the hollow magnetic silybin liquid crystal molecular imprinted polymer (HMS@LC-MIP) was prepared through the reverse atom radical transfer polymerization(RATRP) method. In order to decrease the degree of cross-linker, the liquid crystal ingredient methylphenyl dicyclohexyl ethylene, a kind of physical cross-linker, being able to replace the chemical cross-linker partly, was introduced into the synthetic system. The characterizations of HMS@LC-MIPs were investigated by FT-IR, VSM, TEM and so on. A series of adsorption experiments showed the maximum adsorption capacity and the adsorption equilibrium time of HMS@LC-MIP were 18.53 mg g−1 and 180 min, respectively, and the relative selectivity factor β=2.06 implied HMS@LC-MIP had the high selectivity to the template. The in-vitro release experiments exhibited HMS@LC-MIP possessed the good responsiveness to pH values and the desirable slow release performance with 48 h of sustaining time. In short, the HMS@LC-MIP should be of a potential as drug sustained-release agent in the future.
中文翻译：
水飞蓟宾缓释载体空心磁性液晶分子印迹聚合物的制备及性能
在这项工作中，通过反向原子自由基转移聚合（RATRP）方法制备了一种新型药物载体——空心磁性水飞蓟宾液晶分子印迹聚合物（HMS@LC-MIP）。为了降低交联度，在合成体系中引入了液晶成分甲基苯基二环己基乙烯这种物理交联剂，可以部分替代化学交联剂。通过FT-IR、VSM、TEM等研究了HMS@LC-MIPs的表征。一系列吸附实验表明，HMS@LC-MIP的最大吸附容量和吸附平衡时间分别为18.53 mg g -1和180 min，相对选择性因子β=2.06 表明 HMS@LC-MIP 对模板具有高选择性。体外释放实验表明，HMS@LC-MIP 具有良好的 pH 响应性和理想的缓释性能，持续时间为 48 小时。简而言之，HMS@LC-MIP 有望成为未来的药物缓释剂。
更新日期：2021-09-10
中文翻译：
水飞蓟宾缓释载体空心磁性液晶分子印迹聚合物的制备及性能
在这项工作中，通过反向原子自由基转移聚合（RATRP）方法制备了一种新型药物载体——空心磁性水飞蓟宾液晶分子印迹聚合物（HMS@LC-MIP）。为了降低交联度，在合成体系中引入了液晶成分甲基苯基二环己基乙烯这种物理交联剂，可以部分替代化学交联剂。通过FT-IR、VSM、TEM等研究了HMS@LC-MIPs的表征。一系列吸附实验表明，HMS@LC-MIP的最大吸附容量和吸附平衡时间分别为18.53 mg g -1和180 min，相对选择性因子β=2.06 表明 HMS@LC-MIP 对模板具有高选择性。体外释放实验表明，HMS@LC-MIP 具有良好的 pH 响应性和理想的缓释性能，持续时间为 48 小时。简而言之，HMS@LC-MIP 有望成为未来的药物缓释剂。
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