Self Assemblies of Poly(ether ether ketone) Block Copolymers for Biomedical Applications,ChemistrySelect

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Self Assemblies of Poly(ether ether ketone) Block Copolymers for Biomedical Applications
ChemistrySelect ( IF 1.9 ) Pub Date : 2021-09-09 , DOI: 10.1002/slct.202102238
Avneesh Kumar _{1,

2}

Affiliation

Oriented and ordered domains in an unusual engineering homopolymer known as poly ether ether ketone (PEEK) are stimulated by attaching a phosphonated ionic segment to its both ends. Such orientation of polymer chains leads to the formation of nanoparticles in solution. The ordered domains contain the stacks of rigid polymer chains that result into the crystalline regions appearing in rather unusual manner. Here, the molecular motions and reorganization are reinforced by hydrogen bonds, and not by annealing. On a silicone surface i. e. a substitute for titanium in implants, these copolymer attach via ionic groups and consequently the molecular self assemblies get disrupted. The corresponding copolymer films show submicrometer sized roughness, and hence can improve adhesion significantly. The self assemblies induced and generated simultaneously contain functional groups and can bind to a metallic surface for biomedical applications e. g. bone implants. These block copolymers as bone or dental implants can be superior to the ones based on modified PEEKs where the degree of modification can be problematic and can compromise the properties of PEEK. In addition, tri-block copolymers described here can be better alternatives for bone implants due to their cell adhesion efficiency via ionic groups and thermal stability including reasonable biocompatibility.

中文翻译：

用于生物医学应用的聚（醚醚酮）嵌段共聚物的自组装

聚醚醚酮 (PEEK) 一种不寻常的工程均聚物中的定向和有序结构域是通过在其两端连接一个膦酸化的离子链段来刺激的。聚合物链的这种取向导致溶液中纳米颗粒的形成。有序域包含刚性聚合物链的堆叠，导致结晶区域以相当不寻常的方式出现。在这里，分子运动和重组由氢键增强，而不是通过退火。在硅胶表面上 i. e. 作为植入物中钛的替代品，这些共聚物通过离子基团连接，因此分子自组装被破坏。相应的共聚物薄膜显示出亚微米级的粗糙度，因此可以显着提高附着力。同时诱导和生成的自组装包含官能团，可以结合到金属表面用于生物医学应用。G。骨植入物。这些作为骨或牙科植入物的嵌段共聚物可能优于基于改性 PEEK 的那些，其中改性程度可能存在问题并可能损害 PEEK 的性能。此外，这里描述的三嵌段共聚物可以成为骨植入物的更好替代品，因为它们通过离子基团的细胞粘附效率和热稳定性，包括合理的生物相容性。这些作为骨或牙科植入物的嵌段共聚物可能优于基于改性 PEEK 的那些，其中改性程度可能存在问题并可能损害 PEEK 的性能。此外，这里描述的三嵌段共聚物可以成为骨植入物的更好替代品，因为它们通过离子基团的细胞粘附效率和热稳定性，包括合理的生物相容性。这些作为骨或牙科植入物的嵌段共聚物可能优于基于改性 PEEK 的那些，其中改性程度可能存在问题并可能损害 PEEK 的性能。此外，这里描述的三嵌段共聚物可以成为骨植入物的更好替代品，因为它们通过离子基团的细胞粘附效率和热稳定性，包括合理的生物相容性。

更新日期：2021-09-10

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