The organelle of eukaryotes is a finely regulated system. Once disturbed, it activates the specific autoregulatory systems, namely, organelle autoregulation. Among which, the Golgi stress response accounts for one. When the abundance and capacity of the Golgi apparatus are insufficient compared with cellular demand, the Golgi stress response is activated to enhance the function of the Golgi apparatus. Although the molecular mechanism of the Golgi stress response has not been well characterized yet, it seems to be an important part of the mammalian stress response. In this review, we discuss the current status of research on the six pathways of the mammalian Golgi stress response (the TFE3, heat shock protein 47, CREB3, E26 transformation specific, proteoglycan, and mucin pathways), which regulate the general function of the Golgi apparatus, anti-apoptosis, pro-apoptosis, proteoglycan glycosylation, and mucin glycosylation, respectively.

中文翻译：

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高尔基应激反应：高尔基功能的调节机制

真核生物的细胞器是一个精细调节的系统。一旦受到干扰，它就会激活特定的自动调节系统，即细胞器自动调节。其中，高尔基应激反应占一。当高尔基体的丰度和容量与细胞需求相比不足时，高尔基体的应激反应被激活以增强高尔基体的功能。尽管高尔基体应激反应的分子机制尚未得到很好的表征，但它似乎是哺乳动物应激反应的重要组成部分。在这篇综述中，我们讨论了哺乳动物高尔基体应激反应六种途径（TFE3、热休克蛋白 47、CREB3、E26 转化特异性途径、蛋白多糖和粘蛋白途径）的研究现状，这些途径调节了高尔基体的一般功能。高尔基体，