We introduce perturbative spatial frequency domain imaging (p-SFDI) for fast two-dimensional (2D) mapping of the optical properties and physiological characteristics of skin and cutaneous microcirculation using spatially modulated visible light. Compared to the traditional methods for recovering 2D maps through a pixel-by-pixel inversion, p-SFDI significantly shortens parameter retrieval time, largely avoids the random fitting errors caused by measurement noise, and enhances the image reconstruction quality. The efficacy of p-SFDI is demonstrated by in vivo imaging forearm of one healthy subject, recovering the 2D spatial distribution of cutaneous hemoglobin concentration, oxygen saturation, scattering properties, the melanin content, and the epidermal thickness over a large field of view. Furthermore, the temporal and spatial variations in physiological parameters under the forearm reactive hyperemia protocol are revealed, showing its applications in monitoring temporal and spatial dynamics.

中文翻译：

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使用微扰空间频域成像 (p-SFDI) 对皮肤和皮肤微循环进行体内二维定量成像

我们引入了微扰空间频域成像 (p-SFDI)，用于使用空间调制可见光对皮肤和皮肤微循环的光学特性和生理特征进行快速二维 (2D) 映射。与传统的逐像素反演恢复二维地图的方法相比，p-SFDI显着缩短了参数检索时间，很大程度上避免了测量噪声带来的随机拟合误差，提高了图像重建质量。p-SFDI 的功效通过体内证明对一名健康受试者的前臂成像，在大视野内恢复皮肤血红蛋白浓度、氧饱和度、散射特性、黑色素含量和表皮厚度的二维空间分布。此外，揭示了前臂反应性充血协议下生理参数的时空变化，显示了其在监测时空动态方面的应用。