Carbohydrate Polymers ( IF 10.7 ) Pub Date : 2021-09-10 , DOI: 10.1016/j.carbpol.2021.118662 Yang Zhou 1 , Stella P Petrova 2 , Kevin J Edgar 3
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Polysaccharides are abundant natural polymers, which in nature are at times covalently modified with peptides and proteins. Polysaccharide–protein or polysaccharide–peptide conjugates, natural or otherwise, may have increased solubility, improved emulsion properties, prolonged circulation time, reduced immunogenicity, and enhanced selectivity for targeting specific tissues compared to native peptides and proteins. In this paper, we will review recent advances in synthetic methods for producing polysaccharide–protein conjugates and discuss their advantages with a focus on drug targeting.
中文翻译：
多糖-蛋白质和多糖-肽结合物的化学合成：综述
多糖是丰富的天然聚合物，在自然界中有时会被肽和蛋白质共价修饰。与天然肽和蛋白质相比，天然或其他形式的多糖-蛋白质或多糖-肽缀合物可能具有增加的溶解度、改善的乳液性质、延长的循环时间、降低的免疫原性和增强的靶向特定组织的选择性。在本文中，我们将回顾生产多糖-蛋白质偶联物的合成方法的最新进展，并讨论它们的优势，重点是药物靶向。
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