Gallium indium (GaIn) alloy as a kind of liquid metal (LM) with unique chemical and physical properties has attracted increasing attention for its potential biomedical applications. Herein, a series of core-shell GaIn@Metal (Metal: Pt, Au, Ag, and Cu) heterogeneous nanoparticles (NPs) are obtained by a simple in-situ reduction method. Take core-shell GaIn@Pt NPs for example, the synthesized GaIn@Pt NPs after Pt growth on their surface showed significantly improved photothermal conversion efficiency (PCE) and thermal stability under near-infrared (NIR) II light irradiation. Moreover, the core-shell GaIn@Pt NPs also exhibited good Fenton-like catalytic effect due to the presence of Pt on their surface, and could convert tumor endogenous H₂O₂ to generate reactive oxygen species (ROS) for cancer cell killing. With biocompatible polyethylene glycol (PEG) modification, such GaIn@Pt-PEG NPs showed efficient tumor homing after intravenous injection, and could lead to effective NIR II triggered photothermal-chemodynamic synergistic therapy of tumors as evidenced in a mouse tumor model. Our work highlights the ingenious use of the chemical properties of metals, providing a rather simple route for the surface engineering of LM-based multifunctional nanoplatforms to achieve a variety of functionalities.

镓铟 (GaIn) 合金作为一种液态金属 (LM)，具有独特的化学和物理特性，因其潜在的生物医学应用而受到越来越多的关注。在此，通过简单的原位还原方法获得了一系列核壳型 GaIn@Metal（金属：Pt、Au、Ag 和 Cu）异质纳米粒子（NPs）。以核壳型GaIn@Pt NPs为例，在其表面生长Pt后合成的GaIn@Pt NPs在近红外（NIR）II光照射下显示出显着提高的光热转换效率（PCE）和热稳定性。此外，核壳型GaIn@Pt NPs由于其表面存在Pt，也表现出良好的类芬顿催化作用，可以将肿瘤内源性H ₂ O ₂产生活性氧（ROS）以杀死癌细胞。通过生物相容性聚乙二醇 (PEG) 修饰，这种 GaIn@Pt-PEG NPs 在静脉注射后显示出有效的肿瘤归巢，并可能导致有效的 NIR II 触发的肿瘤光热-化学动力学协同治疗，如小鼠肿瘤模型所示。我们的工作突出了金属化学性质的巧妙利用，为基于 LM 的多功能纳米平台的表面工程实现各种功能提供了一条相当简单的途径。