Next-generation sequencing assisted diagnosis of cervical metastasis in EGFR-mutated lung adenocarcinoma: A case report,Thoracic Cancer

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Next-generation sequencing assisted diagnosis of cervical metastasis in EGFR-mutated lung adenocarcinoma: A case report
Thoracic Cancer ( IF 2.3 ) Pub Date : 2021-09-09 , DOI: 10.1111/1759-7714.14143
Li Xu ₁ , Kang Li ₁ , Xiaoyan Chen ₂ , Bolin Chen ₁ , Jia Li ₁ , Lin Wu ₁

Affiliation

EGFR mutation has been detected in more than half of non-small cell lung cancer (NSCLC) patients in Asia. Lung cancer is the main cause of malignant tumor-related death worldwide. Although distant metastases often occurs in patients with advanced NSCLC, uterine cervical metastasis is rare. Here, we report a case of EGFR-mutated lung adenocarcinoma with cervical metastasis. A 63-year-old female with known lung adenocarcinoma was found to have abnormal vaginal bleeding during osimertinib follow-up visits. Immunohistochemical (IHC) staining and next-generation sequencing (NGS) of the biopsy sample from the uterine cervical tumor confirmed metastatic dissemination from the primary lung malignancy. NGS assisted the diagnosis of uterine cervical metastasis from the primary lung. This is another major clinical application of NGS in addition to medication guidance and identification of drug resistance mechanisms.

中文翻译：

二代测序辅助诊断EGFR突变肺腺癌宫颈转移：一例报告

在亚洲超过一半的非小细胞肺癌 (NSCLC) 患者中检测到EGFR突变。肺癌是全球恶性肿瘤相关死亡的主要原因。虽然晚期NSCLC患者常发生远处转移，但宫颈转移很少见。在这里，我们报告一例EGFR-突变的肺腺癌伴宫颈转移。一名患有已知肺腺癌的 63 岁女性在奥希替尼随访期间发现阴道异常出血。来自子宫颈肿瘤的活检样本的免疫组织化学 (IHC) 染色和下一代测序 (NGS) 证实了原发性肺恶性肿瘤的转移性传播。NGS 辅助诊断原发性肺子宫颈转移。这是NGS在药物指导和耐药机制鉴定之外的又一重大临床应用。

更新日期：2021-10-04

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