Cover illustration refers to the article published in this issue (Wu et al., pp. 1725–1742). The first high-quality safflower genome was presented using single-molecule real-time sequencing, Hi-C mapping technologies, and a genetic linkage map. Multi-omics revealed the regulation of linoleic acid (LA) and flavonoid biosynthesis pathways. Notably, the fatty acid desaturase 2 (FAD2) and chalcone synthase (CHS) families, which function in the LA and flavonoid biosynthesis pathways, respectively, were expanded via tandem duplications in safflower. CarFAD2-12 and other tandemly duplicated CarFAD2 genes were mainly responsible for LA in seeds and ovaries, respectively. CarCHS1, CarCHS4, and tandem duplicated CarCHS6 genes, which were upregulated at early stages, contribute to the accumulation of major flavonoids in flowers.

中文翻译：

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问题信息

封面插图是指本期发表的文章（Wu 等人，第 1725-1742 页）。使用单分子实时测序、Hi-C 作图技术和遗传连锁图呈现了第一个高质量的红花基因组。多组学揭示了亚油酸 (LA) 和类黄酮生物合成途径的调控。值得注意的是，分别在 LA 和类黄酮生物合成途径中起作用的脂肪酸去饱和酶 2 (FAD2) 和查尔酮合酶 (CHS) 家族通过在红花中的串联重复进行了扩增。CarFAD2-12和其他串联复制的CarFAD2基因分别主要负责种子和卵巢中的 LA。CarCHS1、CarCHS4和串联复制的CarCHS6 在早期上调的基因有助于花中主要黄酮类化合物的积累。