Insulin resistance is associated with the incidence of diabetes and cardiovascular diseases such as myocardial infarction. The ratio of triglycerides (TG) to high-density lipoprotein cholesterol (HDL-C) (TG/HDL-C ratio) is positively correlated with insulin resistance. This study aimed to investigate the relationship between the TG/HDL-C ratio and the incidence of diabetes in Korean adults. This retrospective study used data from the National Health Insurance Service-National Health Screening Cohort. The TG/HDL-C ratio was divided into three tertiles, the T1, T2, and T3 groups, based on sex. We estimated the hazard ratios (HRs) and 95% confidence intervals (CIs) for diabetes using multivariate Cox proportional hazards regression analyses. A total of 80,693 subjects aged between 40 and 79 years were enrolled. The median follow-up period was 5.9 years. The estimated cumulative incidence of diabetes in the T1, T2, and T3 groups was 5.94%, 8.23%, and 13.50%, respectively, in men and 4.12%, 4.72%, and 6.85%, respectively, in women. Compared to T1, the fully adjusted HRs (95% CIs) of the T2 and T3 groups for new-onset diabetes were 1.17 (1.06–1.30) and 1.47 (1.34–1.62), respectively, in men and 1.20 (1.02–1.42) and 1.52 (1.30–1.78), respectively, in women. Increased TG/HDL-C ratio was significantly associated with a higher risk of new-onset diabetes in both sexes.

中文翻译：

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韩国成年人甘油三酯与高密度脂蛋白胆固醇的比例与糖尿病发病率呈正相关

胰岛素抵抗与糖尿病和心血管疾病（如心肌梗塞）的发病率有关。甘油三酯 (TG) 与高密度脂蛋白胆固醇 (HDL-C) 的比值 (TG/HDL-C 比值) 与胰岛素抵抗呈正相关。本研究旨在调查 TG/HDL-C 比值与韩国成年人糖尿病发病率之间的关系。这项回顾性研究使用了来自国民健康保险服务 - 国民健康筛查队列的数据。TG/HDL-C 比率根据性别分为三个三分位数，即 T1、T2 和 T3 组。我们使用多变量 Cox 比例风险回归分析估计了糖尿病的风险比 (HR) 和 95% 置信区间 (CI)。共招募了 80,693 名年龄在 40 至 79 岁之间的受试者。中位随访期为 5。9 年。T1、T2 和 T3 组糖尿病的估计累积发病率分别为男性 5.94%、8.23% 和 13.50%，女性分别为 4.12%、4.72% 和 6.85%。与 T1 相比，T2 和 T3 组新发糖尿病的完全调整 HR（95% CI）在男性中分别为 1.17（1.06-1.30）和 1.47（1.34-1.62）和 1.20（1.02-1.42）和 1.52 (1.30–1.78)，分别在女性中。增加的 TG/HDL-C 比率与两性新发糖尿病的风险增加显着相关。分别为男性，女性分别为 1.20 (1.02–1.42) 和 1.52 (1.30–1.78)。增加的 TG/HDL-C 比率与两性新发糖尿病的风险增加显着相关。分别为男性，女性分别为 1.20 (1.02–1.42) 和 1.52 (1.30–1.78)。增加的 TG/HDL-C 比率与两性新发糖尿病的风险增加显着相关。