ABSTRACT

Purpose

To compare and analyze the performance of a device dropper (DD) over conventional drop instillation (CDI) method on ease of administration, compliance, patient satisfaction, and intraocular pressure (IOP) control in persons with glaucoma on ocular hypotensive medications.

Methods

We enrolled 72 individuals with primary open-angle glaucoma or ocular hypertension, on treatment with fixed combination (α agonist+β blocker) drugs for at least 6 months. These were randomized into two groups (36 in each arm). Group 1 administered the drug with a DD and Group 2 used CDI method. Recruited individuals were interviewed for subjective difficulties using a formatted questionnaire at first month follow-up and IOP change from baseline was evaluated.

Results

Baseline demographic and ocular characteristics were similar in both groups. 57.1% in the conventional instillation and none in the DD had reported difficulty in using the eye drops on follow-up visit. DD group had significantly less spillage and contamination of eye surface or dropper tips, required minimal assistance, accurately targeted on first drop placement directly into the eye compared to CDI group (p-value<0.001). Mean IOP was comparable between the two groups.

Conclusion

DD instillation method was observed to be easier to administer, more accurate in targeting the conjunctival cul-de-sac, reduced wastage with lesser contamination compared to the CDI technique. DDs may be expected to have better compliance and effectiveness in medical management of glaucoma.

中文翻译：

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一项随机对照临床试验，比较传统药物滴注与设备滴管方法在青光眼药物治疗中的作用

摘要

目的

比较和分析设备滴管 (DD) 与传统滴注 (CDI) 方法在使用降眼压药物治疗青光眼患者的易用性、依从性、患者满意度和眼压 (IOP) 控制方面的性能。

方法

我们招募了 72 名原发性开角型青光眼或高眼压症患者，他们接受了至少 6 个月的固定组合（α 激动剂 + β 阻滞剂）药物治疗。这些被随机分为两组（每组 36 个）。第 1 组使用 DD 给药，第 2 组使用 CDI 方法。在第一个月的随访中，使用格式化问卷对招募的个人进行了主观困难的采访，并评估了眼压相对于基线的变化。

结果

两组的基线人口统计学和眼部特征相似。57.1% 的常规滴注组和 DD 组均未报告在随访中使用眼药水有困难。与 CDI 组相比，DD 组的眼表或滴管尖端的溢出和污染显着减少，需要最少的帮助，准确地将第一滴液直接放入眼睛中（p值<0.001）。两组的平均眼压相当。

结论

与 CDI 技术相比，观察到 DD 滴注方法更易于管理、更准确地靶向结膜死胡同、减少浪费且污染更小。预计 DD 在青光眼的医疗管理中具有更好的依从性和有效性。