Meiotic recombination affects fertility, shuffles genomes, and modulates the effectiveness of natural selection. Despite conservation of the recombination pathway, the rate of recombination varies among individuals and along chromosomes. Recombination rate also differs among cells from the same organism, but this form of variation has received less attention. To identify patterns that characterize intercellular variation in the genome-wide recombination rate, we counted foci of the MLH1 recombination-associated protein in oocytes and spermatocytes from a panel of wild-derived inbred strains of house mice. Females show higher intercellular variation in MLH1 focus count than males from the same inbred strains. This pattern is consistent across strains from multiple subspecies, including 2 strains in which the average MLH1 focus count is higher in males. The sex difference in genome-wide recombination rate we report suggests that selection targeting recombination rate will be more efficient in males than in females.
Cytogenet Genome Res

中文翻译：

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雌性小鼠全基因组重组率的更高细胞间变异

减数分裂重组会影响生育能力、重组基因组并调节自然选择的有效性。尽管保留了重组途径，但重组率在个体之间和染色体上有所不同。来自同一生物体的细胞之间的重组率也不同，但这种形式的变异受到的关注较少。为了确定表征全基因组重组率的细胞间变异的模式，我们计算了来自一组野生近交系家鼠的卵母细胞和精母细胞中 MLH1 重组相关蛋白的病灶。与来自相同近交系的雄性相比，雌性在 MLH1 焦点计数方面表现出更高的细胞间变异。这种模式在多个亚种的菌株中是一致的，包括 2 个菌株，其中男性的平均 MLH1 焦点计数较高。我们报告的全基因组重组率的性别差异表明，针对重组率的选择在男性中比在女性中更有效。
细胞基因组研究