Propionibacterium acnes, newly reclassified as Cutibacterium acnes, is an anaerobic Gram-positive bacterium causing acne, found mainly on the skin. In addition, P. acnes is responsible for inflammation of the gums (gingivitis) and blood vessels, consequently leading to various diseases in the human body. In recent years, the evolution of microorganisms, such as P. acnes, that have become resistant to many commercial antibiotics due to the widespread use of antimicrobial drugs in the treatment of infectious diseases has emerged as a major clinical problem. We here analyzed the potential use of 37 medicinal plant extracts as plausible candidates for treating P. acnes, in terms of total phenolic and flavonoid contents, antioxidants scavenging and antimicrobial activity. Consequently, methanol extracts from 14 medicinal plants showed promising antimicrobial activities against P. acnes. In particular, as the extracts from Chrysosplenium flagelliferum F. and Thuja orientalis L. exhibited distinct antimicrobial activities in both the broth dilution and disc diffusion assay, they could be effectively used as active ingredients for preventing or treating inflammatory periodontal diseases, such as periodontitis.

中文翻译：

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药用植物提取物抑制牙龈炎和皮肤病原体角质杆菌（丙酸杆菌）痤疮的生长

痤疮丙酸杆菌，新近重新归类为痤疮角质杆菌，是一种厌氧革兰氏阳性菌引起痤疮，主要存在于皮肤上。此外，痤疮丙酸杆菌导致牙龈（牙龈炎）和血管发炎，从而导致人体各种疾病。近年来，由于在感染性疾病治疗中广泛使用抗菌药物，对许多商业抗生素产生抗药性的微生物（例如痤疮丙酸杆菌）的进化已成为主要的临床问题。我们在这里分析了 37 种药用植物提取物作为治疗痤疮丙酸杆菌的可能候选物的潜在用途，就总酚类和黄酮类化合物的含量、抗氧化剂清除和抗菌活性而言。因此，来自 14 种药用植物的甲醇提取物显示出对P 的有希望的抗菌活性。痤疮。特别是，由于Chrysosplenium flagelliferum F. 和Thuja orientalis L.的提取物在肉汤稀释和盘扩散试验中都表现出不同的抗菌活性，因此它们可以有效地用作预防或治疗牙周炎等炎症性牙周病的活性成分。