Antimicrobial peptides constitute one of the most promising alternatives to antibiotics since they could be used to treat bacterial infections, especially those caused by multidrug-resistant pathogens. Many antimicrobial peptides, with various activity spectra and mechanisms of actions, have been described. This review focuses on their use against ESKAPE bacteria, especially in biofilm treatments, their synergistic activity, and their application as prophylactic agents. Limitations and challenges restricting therapeutic applications are highlighted, and solutions for each challenge are evaluated to analyze whether antimicrobial peptides could replace antibiotics in the near future.

中文翻译：

---

抗菌肽：抗生素的有效替代品


抗菌肽是最有前途的抗生素替代品之一，因为它们可用于治疗细菌感染，特别是由多重耐药病原体引起的细菌感染。已经描述了许多具有不同活性谱和作用机制的抗菌肽。本综述重点关注它们对抗 ESKAPE 细菌的用途，特别是在生物膜治疗中、它们的协同活性以及它们作为预防剂的应用。强调了限制治疗应用的局限性和挑战，并对每个挑战的解决方案进行了评估，以分析抗菌肽是否可以在不久的将来取代抗生素。