Abstract

The emergence of nanotechnology provides a new method for the development and application of nanomaterials in the medical field. Nanoparticles could promote the expression of vascular endothelial growth factor (VEGF), dilate the coronary artery, improve the cardiac mechanism and reduce the recurrence rate of angina pectoris. Nanoparticles have the advantages of large specific surface area, high surface reactivity, high catalytic efficiency and strong adsorption capacity, which provide a new method for biomedical research. This paper mainly studies the application of nanoparticles in the diagnosis and treatment of coronary artery disease under the intervention of exercise rehabilitation. Then the prepared nanoparticles were added into the medium for co culture. The effect of nanoparticles on coronary cells was observed. It was found that the detection of zinc in the extracellular medium and in the cell increased with the increase of the concentration of ZnO NPs, and the differences were statistically significant (F = 13012.34, P < 0.001; F = 7033.54, P < 0.001). The results showed that the nanoparticles could promote the expression of vascular endothelial growth factor (VEGF), dilate the coronary artery, improve the cardiac mechanism and reduce the recurrence rate of angina pectoris.

摘要

纳米技术的出现为纳米材料在医学领域的开发和应用提供了新的途径。纳米颗粒可促进血管内皮生长因子（VEGF）的表达，扩张冠状动脉，改善心脏机制，降低心绞痛复发率。纳米粒子具有比表面积大、表面反应活性高、催化效率高、吸附能力强等优点，为生物医学研究提供了一种新方法。本文主要研究纳米粒子在运动康复干预下冠心病诊治中的应用。然后将制备的纳米颗粒加入培养基中进行共培养。观察纳米颗粒对冠状细胞的作用。发现随着ZnO NPs浓度的增加，细胞外培养基和细胞内锌的检出量增加，差异有统计学意义（F = 13012.34，P < 0.001；F = 7033.54，P < 0.001） . 结果表明，纳米颗粒能够促进血管内皮生长因子（VEGF）的表达，扩张冠状动脉，改善心脏机制，降低心绞痛复发率。