Abstract

Biofilms of pathogenic bacteria in the body of an infected host are complex structures often formed by microorganisms of different species. They are resistant to antibiotics and other antimicrobial agents, host immune systems, and adverse environmental conditions; exhibit increased survival; and are responsible for most known chronic infections that cannot be treated with antibiotics. This situation has required an increased search for alternative ways to combat biofilm infections. This review examines the most promising developments aimed at destroying bacterial biofilms that cause chronic diseases.

中文翻译：

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细菌生物膜在慢性感染过程中的作用以及对抗它们的方法的探索

摘要

受感染宿主体内病原菌的生物膜是复杂的结构，通常由不同物种的微生物形成。它们对抗生素和其他抗微生物剂、宿主免疫系统和不利的环境条件具有抗性；表现出增加的存活率；并且是大多数已知的不能用抗生素治疗的慢性感染的原因。这种情况需要更多地寻找对抗生物膜感染的替代方法。这篇综述审查了旨在破坏导致慢性疾病的细菌生物膜的最有希望的发展。