ABSTRACT

Purpose

Retinitis pigmentosa (RP) is a group of degenerative retinal diseases characterized by mutations in genes affecting retinal pigment epithelium (RPE) function, as well as mutations directly involving photoreceptors. This paper aims to evaluate a nonlinear method to distinguish between the RP and normal eye based on the Electroretinogram (ERG) signal.

Method

ERG signal was recorded from 28 eyes of patients with the RP and 32 normal eyes. The ERG signal consists of four different stimuli, including two dark-adapted and two light-adapted stimuli. The time-domain analysis includes the amplitude and implicit time to consider the robustness of the nonlinear method. A parabolic mapping method was performed, and two criteria (Theta angle and density) extracted from the parabola were compared for both groups.

Results

The results showed that a-wave’s amplitude and implicit time significantly changed in the dark- and light-adapted stimuli. The amplitude of the b-wave showed significant changes in all stimuli. However, the implicit time of b-wave had a significant increase only in the dark-adapted 3.0 ERG. Both nonlinear criteria showed significant changes in the RP group for all the stimuli. The p-values of dark-adapted 3.0 (p = .0121), dark-adapted 10.0 (p = .0014), light-adapted 3.0 (p = .0119), and flicker 30 Hz (p = .0323) showed significant differences. Using the density criterion, the statistical test demonstrated a significant difference between the RP and healthy normal group in dark-adapted 3.0 (p = .0076), dark-adapted 10.0 (p = .0024), light-adapted 3.0 (p = .0021), and flicker 30 Hz (p = .0165).

Conclusion

The proposed features have made it possible to distinguish between healthy and RP eyes. This method might be helpful in early diagnosis.

中文翻译：

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映射方法在色素性视网膜炎患者视网膜电图分析中的应用

摘要

目的

色素性视网膜炎 (RP) 是一组以影响视网膜色素上皮 (RPE) 功能的基因突变以及直接涉及光感受器的突变为特征的退行性视网膜疾病。本文旨在评估一种基于视网膜电图 (ERG) 信号区分 RP 和正常眼睛的非线性方法。

方法

从 RP 患者的 28 只眼和 32 只正常眼中记录 ERG 信号。ERG 信号由四种不同的刺激组成，包括两种暗适应刺激和两种光适应刺激。时域分析包括幅度和隐含时间，以考虑非线性方法的鲁棒性。进行了抛物线映射方法，并对两组从抛物线中提取的两个标准（θ角和密度）进行了比较。

结果

结果表明，a波的幅度和隐含时间在暗适应和光适应刺激下发生显着变化。b 波的幅度在所有刺激中都显示出显着的变化。然而，b 波的隐含时间仅在暗适应 3.0 ERG 中显着增加。两种非线性标准都显示 RP 组在所有刺激下都有显着变化。暗适应 3.0 ( p =  .0121 )、暗适应 10.0 ( p =  .0014)、光适应 3.0 ( p =  .0119) 和闪烁 30 Hz ( p =  .0323) 的 p 值显示显着差异。使用密度标准，统计检验表明暗适应 3.0 中 RP 和健康正常组之间存在显着差异（p = .0076)、暗适应 10.0 ( p =  .0024)、光适应 3.0 ( p =  .0021) 和闪烁 30 Hz ( p =  .0165)。

结论

所提出的特征使得区分健康眼和 RP 眼成为可能。这种方法可能有助于早期诊断。