The lack of targeting selection to lysosome limits the application of graphene quantum dots (GQDs) in the diagnosis and treatment of lysosome-related disease. In this study, we developed a facile, environmentally friendly and large-scale method to prepare N-aminomorpholine (Am)-modified GQDs (Am-GQDs) via a simple hydrothermal method. The physicochemical, optical, biocompatible and targeted imaging properties were evaluated systematically. The results indicated that the synthesized Am-GQDs had a uniform size distribution and the size was around 2nm. In addition, the synthesized Am-GQDs had excellent optical properties, fluorescent stability, and good biocompatibility. More importantly, they can selectively target and image lysosome in a relatively short coculture time with cells, demonstrating their application potential in the diagnosis and treatment of lysosomal-related diseases.

中文翻译：

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用吗啉功能化石墨烯量子点的简便和大规模合成用于溶酶体的选择性靶向和成像

缺乏对溶酶体的靶向选择限制了石墨烯量子点（GQD）在溶酶体相关疾病诊断和治疗中的应用。在这项研究中，我们开发了一种简便、环保、大规模的制备方法ñ-氨基吗啉 (Am) 修饰的 GQDs (Am-GQDs) 通过简单的水热法。系统地评估了物理化学、光学、生物相容性和靶向成像特性。结果表明，合成的 Am-GQDs 尺寸分布均匀，尺寸约为 2纳米。此外，合成的Am-GQDs具有优异的光学性能、荧光稳定性和良好的生物相容性。更重要的是，它们可以在相对较短的细胞共培养时间内选择性地靶向和成像溶酶体，展示了它们在溶酶体相关疾病诊断和治疗中的应用潜力。