Autism spectrum disorder (ASD) is a developmental disorder characterised by deficits in social interactions and communication, with stereotypical and repetitive behaviours. Recent evidence suggests that maternal immune dysregulation may predispose offspring to ASD. Independent samples t-tests revealed downregulation of IL-17A concentrations in cases, when compared to controls, at both 15 weeks (p = 0.02), and 20 weeks (p = 0.02), which persisted at 20 weeks following adjustment for confounding variables. This adds to the growing body of evidence that maternal immune regulation may play a role in foetal neurodevelopment.

中文翻译：

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自闭症谱系障碍儿童母亲的孕中期细胞因子失调

自闭症谱系障碍 (ASD) 是一种发育障碍，其特征是社交互动和沟通障碍，具有刻板和重复的行为。最近的证据表明，母体免疫失调可能使后代易患 ASD。独立样本 t 检验显示，与对照组相比，IL-17A 浓度在 15 周（p = 0.02）和 20 周（p = 0.02）时下调，在调整混杂变量后持续 20 周。这增加了越来越多的证据表明母体免疫调节可能在胎儿神经发育中发挥作用。