There is increasing interest in investigating cannabis for behavioral symptoms in individuals with autism spectrum disorder (ASD). The potential role of dysregulated cannabinoid signaling contributing to the pathophysiology of ASD is an area of active investigation. Results from retrospective and uncontrolled trials of cannabis in subjects with ASD have been published, reporting both potential benefits and adverse effects. Here, we describe the clinical course of three young adult males with ASD who developed mania or psychosis after the consistent use of cannabidiol and delta-9-tetrahydrocannabinol. Caution should be utilized with cannabis use in individuals with ASD until large-scale, replicated randomized controlled trials demonstrating efficacy, safety and tolerability have been published.

人们越来越关注研究大麻在自闭症谱系障碍 (ASD) 患者中的行为症状。失调的大麻素信号传导导致 ASD 的病理生理学的潜在作用是一个积极研究的领域。大麻在 ASD 受试者中的回顾性和非对照试验的结果已经发表，报告了潜在的益处和不良反应。在这里，我们描述了三名患有 ASD 的年轻成年男性在持续使用大麻二酚和 delta-9-四氢大麻酚后出现躁狂或精神病的临床过程。在证明有效性、安全性和耐受性的大规模、可重复的随机对照试验发表之前，应谨慎对待 ASD 患者的大麻使用。