Lateral preoptic area neurons signal cocaine self-administration behaviors,European Journal of Neuroscience

当前位置： X-MOL 学术 › Eur. J. Neurosci. › 论文详情

Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)

Lateral preoptic area neurons signal cocaine self-administration behaviors
European Journal of Neuroscience ( IF 2.7 ) Pub Date : 2021-09-09 , DOI: 10.1111/ejn.15452
Kevin R. Coffey ₁ , Vaishnavi Venkat ₂ , Mark O. West ₂ , David J. Barker ₂

Affiliation

The lateral preoptic area is implicated in numerous aspects of substance use disorder. In particular, the lateral preoptic area is highly sensitive to the pharmacological properties of psychomotor stimulants, and its activity promotes drug-seeking in the face of punishment and reinstatement during abstinence. Despite the lateral preoptic area's complicity in substance use disorder, how precisely lateral preoptic area neurons signal the individual components of drug self-administration has not been ascertained. To bridge this gap, we examined how the firing of single lateral preoptic area neurons correlates with three discrete elements of cocaine self-administration: (1) drug-seeking (pre-response), (2) drug-taking (response) and (3) receipt of the cocaine infusion. A significant subset of lateral preoptic area neurons responded to each component with a mix of increases and decreases in firing-rate. A majority of these neurons signal the operant response with increases in spiking, though responses during the drug-seeking, taking and reciept windows were highly correlated.

中文翻译：

外侧视前区神经元信号可卡因自我管理行为

外侧视前区与物质使用障碍的许多方面有关。特别是，外侧视前区对精神运动兴奋剂的药理特性高度敏感，其活性促进了在禁欲期间面对惩罚和恢复的寻求药物。尽管外侧视前区与物质使用障碍有关，但尚未确定外侧视前区神经元向药物自我给药的各个组成部分发出信号的精确程度。为了弥补这一差距，我们研究了单侧视前区神经元的放电如何与可卡因自我给药的三个离散要素相关联：（1）寻求药物（预反应），（2）吸毒（反应）和（ 3) 接受可卡因输液。外侧视前区神经元的一个重要子集对每个组件做出反应，同时增加和减少放电率。尽管在寻求药物、服用和接受药物窗口期间的反应高度相关，但这些神经元中的大多数会随着尖峰信号的增加而发出操作性反应的信号。

更新日期：2021-10-20

点击分享查看原文

点击收藏

公开下载

阅读更多本刊最新论文本刊介绍/投稿指南11