Abstract

The process of forming hybrid microparticles from a biodegradable polyester, that is, polylactide, and hydroxyapatite nanoparticles, which can be promising as cellular microcarriers or starting materials for obtaining three-dimensional scaffolds for bone tissue regeneration, has been investigated. A method has been developed for fabricating hybrid microparticles by evaporation of solvents from oil/water emulsions without the use of additional emulsifiers in a dispersion phase. It is shown that hydroxyapatite nanoparticles can effectively stabilize the interface during the preparation of microparticles. The effect of the concentration of hydroxyapatite nanoparticles and their preliminary dispersion using ultrasonic treatment on the yield of microparticles, their size distribution and morphology was evaluated.

中文翻译：

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基于聚乳酸和羟基磷灰石纳米颗粒的用于骨组织再生的可生物降解微粒

摘要

已经研究了由可生物降解的聚酯（即聚交酯和羟基磷灰石纳米粒子）形成混合微粒的过程，这些微粒可作为细胞微载体或起始材料用于获得用于骨组织再生的三维支架。已经开发了一种通过从油/水乳液中蒸发溶剂来制造混合微粒的方法，而无需在分散相中使用额外的乳化剂。结果表明，羟基磷灰石纳米粒子可以在微粒制备过程中有效地稳定界面。评估了羟基磷灰石纳米颗粒的浓度及其使用超声波处理的初步分散对微粒产率、它们的尺寸分布和形态的影响。