Zinc Ferrite (ZnFe₂O₄, ZFO) nanoparticles (NPs) as a multi-sensing material are successfully synthesised via a hydrothermal method and a following annealing treatment. The as-prepared ZFO-NPs were applied in electrochemical and mass-type sensors by depositing NPs directly on the screen-printed electrode (SPE) and the active electrode of a quartz crystal microbalance (QCM), respectively. The obtained results show the ZFO-NPs possessed excellent detection performance to sulphur dioxide (SO₂) in the range of 2.5–20 ppm at room temperature. QCM sensor coated with ZFO-NPs showed a high response, good repeatability, as well as short-response time. Moreover, the modified-SPE with ZFO-NPs sensitively responded to chloramphenicol (CAP) of concentration range from 5 to 50 μM in phosphate buffer solution (PBS). The sensing mechanism of ZFO-NPs based sensors towards SO₂ and CAP was also discussed. This study demonstrates that ZFO-NPs could be known as a potential sensor material capable of detecting SO₂ gas and CAP quickly in both mass-type gas sensors and electrochemical sensors.

锌铁氧体（ZnFe ₂ O ₄，ZFO）纳米颗粒（NPs）作为多传感材料通过水热法和后续退火处理成功合成。通过将纳米粒子直接沉积在丝网印刷电极 (SPE) 和石英晶体微天平 (QCM) 的活性电极上，将制备的 ZFO-NPs 应用于电化学和质量型传感器。结果表明，ZFO-NPs对二氧化硫（SO ₂) 在室温下的 2.5–20 ppm 范围内。涂有 ZFO-NP 的 QCM 传感器显示出高响应、良好的可重复性和短响应时间。此外，带有 ZFO-NP 的改性 SPE 对磷酸盐缓冲溶液 (PBS) 中浓度范围为 5 至 50 μM 的氯霉素 (CAP) 敏感。还讨论了基于 ZFO-NPs 的传感器对 SO ₂和 CAP的传感机制。该研究表明，ZFO-NPs 可以作为一种潜在的传感器材料，能够在质量型气体传感器和电化学传感器中快速检测 SO ₂气体和 CAP。