We conducted a systematic review and meta-analysis investigating the association between overweight and outcome in triple-negative breast cancer (TNBC) patients. We searched PubMed and Embase using variations of the search terms triple-negative breast cancer (population), overweight and/or obesity (exposure), and prognosis (outcome). Based on the World Health Organization guidelines for defining overweight, we included longitudinal observational studies, which utilized survival statistics with hazard ratios (HRs) in our analysis. The included studies measured body mass index at the time of diagnosis of TNBC and reported disease-free survival and/or overall survival. Study quality was assessed with the Newcastle-Ottawa Scale and study data were extracted using the Meta-analysis of Observational Studies in Epidemiology (MOOSE) checklist, independently by two authors. Random-effects models were used to combine the effect sizes (HRs), and the results were evaluated and adjusted for possible publication bias. Thirteen studies of 8,944 TNBC patients were included. The meta-analysis showed that overweight was associated with both shorter disease-free survival (HR = 1.26; 95%CI: 1.09–1.46) and shorter overall survival (HR = 1.29; 95%CI: 1.11c1.51) compared to normal-weight. Additionally, our Bayesian meta-analyses suggest that overweight individuals are 7.4 and 9.9 times more likely to have shorter disease-free survival and overall survival, respectively. In conclusion, the available data suggest that overweight is associated with shorter disease-free and overall survival among TNBC patients. The results should be interpreted with caution due to possible publication bias.

我们进行了一项系统回顾和荟萃分析，调查了三阴性乳腺癌 (TNBC) 患者超重与预后之间的关联。我们使用搜索词三阴性乳腺癌（人口）、超重和/或肥胖（暴露）和预后（结果）的变体来搜索 PubMed 和 Embase. 根据世界卫生组织定义超重的指南，我们纳入了纵向观察性研究，在我们的分析中使用了生存统计和风险比 (HR)。纳入的研究测量了 TNBC 诊断时的体重指数，并报告了无病生存率和/或总生存率。研究质量使用纽卡斯尔-渥太华量表进行评估，研究数据使用流行病学观察性研究的荟萃分析 (MOOSE) 清单提取，由两位作者独立完成。随机效应模型用于组合效应量 (HR)，并针对可能的发表偏倚对结果进行评估和调整。包括 8,944 名 TNBC 患者的 13 项研究。荟萃分析表明，超重与较短的无病生存期相关（HR = 1.26；95% CI：1。09–1.46) 和比正常体重更短的总生存期 (HR = 1.29; 95% CI: 1.11c1.51)。此外，我们的贝叶斯荟萃分析表明，超重个体的无病生存期和总生存期较短的可能性分别是 7.4 和 9.9 倍。总之，现有数据表明，在 TNBC 患者中，超重与较短的无病生存期和总生存期有关。由于可能的发表偏倚，应谨慎解释结果。现有数据表明，超重与 TNBC 患者的无病生存期和总生存期较短有关。由于可能的发表偏倚，应谨慎解释结果。现有数据表明，超重与 TNBC 患者的无病生存期和总生存期较短有关。由于可能的发表偏倚，应谨慎解释结果。