Vitamin D receptor (VDR) signaling has been found to contribute to the pathology of numerous neuropsychiatric diseases including schizophrenia. Notably, VDR signaling has a functional relationship with many long non-coding RNAs (lncRNAs) such as SNHG6, LINC00346 and LINC00511. We calculated expression of these lncRNAs in the venous blood of patients with schizophrenia versus healthy individuals. Expression of SNHG6 was significantly higher in cases versus controls (posterior beta = 0.552, adjusted P value < 0.0001). This pattern of expression was detected in both men (posterior beta = 0.556, adjusted P value < 0.0001) and women (posterior beta = 0.31, adjusted P value = 0.005). Expression of LINC00346 was also higher in cases versus controls (posterior beta = 0.497, adjusted P value < 0.0001) and in distinct sex-based comparisons (posterior beta = 0.451, adjusted P value = 0.009 among men and posterior beta = 0.214, P value = 0.004 among women). Expression of LINC00511 was higher in cases versus controls (posterior beta = 0.318, adjusted P value = 0.01). While sex-based comparisons revealed significant difference in expression of LINC00511 among female subgroups (posterior beta = 0.424, adjusted P value = 0.016), such comparison showed no difference among male cases and male controls (adjusted P value = 0.295). The expression levels of SNHG6 distinguished patients with schizophrenia from controls, with AUC = 0.932. LINC00346 and LINC00511 distinguished between the two groups with AUC values of 0.795 and 0.706, respectively. Therefore, these lncRNAs might be used as markers for schizophrenia.

已发现维生素 D 受体 (VDR) 信号传导导致包括精神分裂症在内的许多神经精神疾病的病理学。值得注意的是，VDR 信号传导与许多长链非编码 RNA (lncRNA) 具有功能关系，例如SNHG6、LINC00346和LINC00511。我们计算了这些 lncRNA 在精神分裂症患者与健康个体的静脉血中的表达。与对照组相比，病例中SNHG6 的表达显着更高（后β = 0.552，调整后的P值 < 0.0001）。这种表达模式在男性（后β = 0.556，调整后的P值 < 0.0001）和女性（后β = 0.31，调整后的P值 = 0.005）。LINC00346在病例中的表达也高于对照组（后β = 0.497，调整后的P值 < 0.0001）和不同的基于性别的比较（后β = 0.451，调整后的P值 = 0.009 男性和后β = 0.214，P值= 0.004 女性）。与对照组相比，LINC00511 的表达在病例中更高（后β = 0.318，调整后的P值 = 0.01）。虽然基于性别的比较显示，LINC00511在女性亚组中的表达存在显着差异（后验β = 0.424，调整后的P值 = 0.016），这种比较显示男性病例和男性对照之间没有差异（调整后的P值 = 0.295）。SNHG6的表达水平将精神分裂症患者与对照组区分开来，AUC = 0.932。LINC00346和LINC00511区分了两组，AUC 值分别为 0.795 和 0.706。因此，这些 lncRNA 可能被用作精神分裂症的标志物。