SERS substrate fabrication for biochemical sensing: towards point-of-care diagnostics,Journal of Materials Chemistry B

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SERS substrate fabrication for biochemical sensing: towards point-of-care diagnostics
Journal of Materials Chemistry B ( IF 6.1 ) Pub Date : 2021-08-27 , DOI: 10.1039/d1tb01299a
Xiaojia Liu _{1,

2} , Jiuchuan Guo ₃ , Yang Li ₄ , Bo Wang ₄ , Shikun Yang _{1,

2} , Wenjun Chen _{1,

2} , Xinggui Wu ₅ , Jinhong Guo ₃ , Xing Ma _{1,

2}

Affiliation

Rapid technology development and economic growth have brought attention to public health issues, such as food safety and environmental pollution, which creates an ever-increasing demand for fast and portable sensing technologies. Portable surface-enhanced Raman spectroscopy (SERS) capable of various analyte detection with low concentration in a convenient manner shows advantages in sensing technology including enhanced diagnostic precision, improved diagnostic efficiency, reduced diagnostic cost, and alleviation of patient pain, which emerges as a promising candidate for point-of-care testing (POCT). SERS detection technology based on different nanostructures made of noble metal-based nanomaterials can increase the sensitivity of Raman scattering by 6–8 orders of magnitude, making Raman based trace detection possible, and greatly promote the application scenarios of portable Raman spectrometers. In this perspective, we provide an overview of fundamental knowledge about the SERS mechanism including chemical and electromagnetic field enhancement mechanisms, the design and fabrication of SERS substrates based on materials, progress of using SERS for POCT in biochemical sensing and its clinical applications. Furthermore, we present the prospective of developing new nanomaterials with different functionalities for advanced SERS substrates, as well as the future advancement of biomedical sensing and clinical potential of SERS technology.

中文翻译：

用于生化传感的 SERS 基板制造：面向即时诊断

快速的技术发展和经济增长引起了人们对食品安全和环境污染等公共卫生问题的关注，这对快速和便携式传感技术的需求不断增加。便携式表面增强拉曼光谱（SERS）能够方便地检测低浓度的各种分析物，在传感技术方面具有优势，包括提高诊断精度、提高诊断效率、降低诊断成本和减轻患者疼痛，成为一种很有前途的应用。床旁检测 (POCT) 的候选者。基于贵金属基纳米材料制成的不同纳米结构的SERS检测技术可以将拉曼散射的灵敏度提高6-8个数量级，使基于拉曼的痕量检测成为可能，极大地推动了便携式拉曼光谱仪的应用场景。从这个角度出发，我们概述了有关 SERS 机制的基础知识，包括化学和电磁场增强机制、基于材料的 SERS 基板的设计和制造、将 SERS 用于 POCT 在生化传感中的进展及其临床应用。此外，我们还介绍了为先进的 SERS 基板开发具有不同功能的新型纳米材料的前景，以及生物医学传感的未来发展和 SERS 技术的临床潜力。基于材料的SERS基板的设计与制备、SERS在POCT中的生化传感及其临床应用进展。此外，我们还介绍了为先进的 SERS 基板开发具有不同功能的新型纳米材料的前景，以及生物医学传感的未来发展和 SERS 技术的临床潜力。基于材料的SERS基板的设计与制备、SERS在POCT中的生化传感及其临床应用进展。此外，我们还介绍了为先进的 SERS 基板开发具有不同功能的新型纳米材料的前景，以及生物医学传感的未来发展和 SERS 技术的临床潜力。

更新日期：2021-09-10

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