Multifunctional Ca–Zn–Si-based micro-nano spheres with anti-infective, anti-inflammatory, and dentin regenerative properties for pulp capping application,Journal of Materials Chemistry B

当前位置： X-MOL 学术 › J. Mater. Chem. B › 论文详情

Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)

Multifunctional Ca–Zn–Si-based micro-nano spheres with anti-infective, anti-inflammatory, and dentin regenerative properties for pulp capping application
Journal of Materials Chemistry B ( IF 6.1 ) Pub Date : 2021-08-23 , DOI: 10.1039/d1tb01517f
Zhengmao Li ₁ , Kunke Xie ₁ , Shuang Yang ₁ , Ting Yu ₁ , Yin Xiao _{1,

2} , Yinghong Zhou _{1,

2}

Affiliation

While pulp capping using a variety of materials has been applied clinically to preserve the health and vitality of the dental pulp and induce dentin repair no material meets all the anti-infection, anti-inflammation, and promoting pulp tissue regeneration criteria. Micro–nano materials of bioactive glasses (BG) with the biocompatibility and osteogenesis-promoting properties were developed for this study using Zn-doped bioactive glass (BGz) micro–nano spheres for dental pulp capping to control infection and inflammation and promote tissue regeneration. Of three key findings, the co-culture of Porphyromonas gingivalis showed that the BGz had an excellent antibacterial effect, and after being stimulated with BGz in vitro, macrophages showed a significant decrease of pro-inflammatory M1 markers compared with the undoped BG group. It is also noted that the conditioned medium derived from BGz-stimulated macrophages could significantly promote mineralized dentin formation of dental pulp cells (DPCs). In rats, acute pulp restoration experiments proved that BGz used as a pulp capping agent had excellent dentin regenerative properties. This work may provide a novel strategy to promote osteo/dentinogenic differentiation through regulating early inflammation, with potential applications in pulp capping.

中文翻译：

具有抗感染、抗炎和牙本质再生特性的多功能 Ca-Zn-Si 基微纳米球，用于盖髓应用

虽然临床上使用多种材料进行的牙髓覆盖以保持牙髓的健康和活力并诱导牙本质修复，但没有一种材料符合所有抗感染、抗炎和促进牙髓组织再生的标准。本研究开发了具有生物相容性和促进成骨特性的生物活性玻璃（BG）微纳米材料，使用锌掺杂的生物活性玻璃（BGz）微纳米球进行牙髓覆盖，以控制感染和炎症并促进组织再生。在三个关键发现中，牙龈卟啉单胞菌的共培养表明 BGz 具有出色的抗菌作用，并且在体外用 BGz 刺激后，与未掺杂的 BG 组相比，巨噬细胞显示促炎 M1 标志物显着减少。还值得注意的是，源自 BGz 刺激的巨噬细胞的条件培养基可以显着促进牙髓细胞 (DPC) 的矿化牙本质形成。在大鼠中，急性牙髓修复实验证明，用作盖髓剂的 BGz 具有优异的牙本质再生性能。这项工作可能提供一种通过调节早期炎症来促进骨/牙本质分化的新策略，并在盖髓中具有潜在应用。

更新日期：2021-09-10

点击分享查看原文

点击收藏

阅读更多本刊最新论文本刊介绍/投稿指南11