A sequentially activated bioluminescent probe for observation of cellular H2O2 production induced by cysteine,Chemical Communications

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A sequentially activated bioluminescent probe for observation of cellular H2O2 production induced by cysteine
Chemical Communications ( IF 4.3 ) Pub Date : 2021-09-03 , DOI: 10.1039/d1cc04015d
Kaiqing Ma ₁ , Yongkang Yue ₁ , Lingling Zhao ₁ , Jianbin Chao ₂ , Caixia Yin ₁

Affiliation

We report herein a caged luciferin probe Cy-Hy as a sequentially activated probe to selectively and sensitively sense L-Cys and H₂O₂. The probe displayed fluorescence and bioluminescence responses toward the two analytes. Utilizing the present probe, cellular excess L-Cys-induced H₂O₂ up-regulation was observed for the first time in living MDA-MB-231 cells.

中文翻译：

一种顺序激活的生物发光探针，用于观察半胱氨酸诱导的细胞 H2O2 产生

我们在此报告了笼状荧光素探针Cy-Hy作为顺序激活的探针，以选择性和灵敏地检测L -Cys 和 H ₂ O ₂。该探针对两种分析物显示出荧光和生物发光反应。利用本探针，首次在活的 MDA-MB-231 细胞中观察到细胞过量的L -Cys 诱导的 H ₂ O ₂上调。

更新日期：2021-09-10

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