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The Immune-Related Gene ELF3 is a Novel Biomarker for the Prognosis of Ovarian Cancer
International Journal of General Medicine ( IF 2.3 ) Pub Date : 2021-09-10 , DOI: 10.2147/ijgm.s332320 Hao Xu 1 , Haihong Wang 2 , Guilin Li 3 , Xin Jin 3 , Buze Chen 2, 4
International Journal of General Medicine ( IF 2.3 ) Pub Date : 2021-09-10 , DOI: 10.2147/ijgm.s332320 Hao Xu 1 , Haihong Wang 2 , Guilin Li 3 , Xin Jin 3 , Buze Chen 2, 4
Affiliation
Background: Ovarian cancer (OC) is a fatal gynaecological malignancy. The study aimed to conduct a comprehensive study to determine the role of ELF3 in OC through bioinformatic analysis.
Methods: Kruskal–Wallis test, Wilcoxon sign-rank test, and logistic regression were used to evaluate the relationship between clinical characteristics and ELF3 expression. Kaplan–Meier method and Cox regression analysis were used to evaluate the prognostic factors. Gene set enrichment analysis (GSEA) and immuno-infiltration analysis were used to evaluate the significant involvement of ELF3 in function.
Results: High ELF3 expression in OC was associated with age (P< 0.001). High ELF3 expression predicted a poorer overall survival (OS) (HR: 1.37; 95% CI: 1.05– 1.78; P=0.019) and disease specific survival (DSS) (HR: 1.43; 95% CI: 1.08– 1.89; P=0.013). And ELF3 expression (HR: 1.779; 95% CI: 1.281– 2.472; P< 0.001) was independently correlated with OS in OC patients. GSEA demonstrated that pathways including GPCR-ligand binding, neuronal system, signaling by WNT, translation, neuroactive ligand-receptor interaction, and TCF dependent signaling in response to WNT were differentially enriched in ELF3 low expression phenotype. Immune infiltration analysis showed that ELF3 expression was correlated with immune infiltrates.
Conclusion: ELF3 expression in OC patients was significantly associated with poor survival and immune infiltration and a promising prognostic biomarker in OC.
中文翻译：
免疫相关基因ELF3是卵巢癌预后的新型生物标志物
背景：卵巢癌（OC）是一种致命的妇科恶性肿瘤。该研究旨在通过生物信息学分析进行全面研究，以确定 ELF3 在 OC 中的作用。
方法：采用 Kruskal-Wallis 检验、Wilcoxon 符号秩检验和逻辑回归评估临床特征与 ELF3 表达之间的关系。Kaplan-Meier方法和Cox回归分析用于评估预后因素。基因集富集分析 (GSEA) 和免疫浸润分析用于评估 ELF3 在功能中的显着参与。
结果：OC 中的高 ELF3 表达与年龄相关（P<0.001）。高 ELF3 表达预测较差的总生存期 (OS) (HR: 1.37; 95% CI: 1.05-1.78; P=0.019) 和疾病特异性生存期 (DSS) (HR: 1.43; 95% CI: 1.08-1.89; P= 0.013)。并且 ELF3 表达（HR：1.779；95% CI：1.281-2.472；P<0.001）与 OC 患者的 OS 独立相关。GSEA 表明，包括 GPCR 配体结合、神经元系统、WNT 信号传导、翻译、神经活性配体-受体相互作用和 TCF 依赖性信号传导以响应 WNT 在内的途径在 ELF3 低表达表型中差异丰富。免疫浸润分析显示ELF3表达与免疫浸润相关。
结论：OC 患者中的 ELF3 表达与较差的生存率和免疫浸润显着相关，并且是 OC 中一个有希望的预后生物标志物。
更新日期：2021-09-10
Methods: Kruskal–Wallis test, Wilcoxon sign-rank test, and logistic regression were used to evaluate the relationship between clinical characteristics and ELF3 expression. Kaplan–Meier method and Cox regression analysis were used to evaluate the prognostic factors. Gene set enrichment analysis (GSEA) and immuno-infiltration analysis were used to evaluate the significant involvement of ELF3 in function.
Results: High ELF3 expression in OC was associated with age (P< 0.001). High ELF3 expression predicted a poorer overall survival (OS) (HR: 1.37; 95% CI: 1.05– 1.78; P=0.019) and disease specific survival (DSS) (HR: 1.43; 95% CI: 1.08– 1.89; P=0.013). And ELF3 expression (HR: 1.779; 95% CI: 1.281– 2.472; P< 0.001) was independently correlated with OS in OC patients. GSEA demonstrated that pathways including GPCR-ligand binding, neuronal system, signaling by WNT, translation, neuroactive ligand-receptor interaction, and TCF dependent signaling in response to WNT were differentially enriched in ELF3 low expression phenotype. Immune infiltration analysis showed that ELF3 expression was correlated with immune infiltrates.
Conclusion: ELF3 expression in OC patients was significantly associated with poor survival and immune infiltration and a promising prognostic biomarker in OC.
中文翻译：
免疫相关基因ELF3是卵巢癌预后的新型生物标志物
背景：卵巢癌（OC）是一种致命的妇科恶性肿瘤。该研究旨在通过生物信息学分析进行全面研究，以确定 ELF3 在 OC 中的作用。
方法：采用 Kruskal-Wallis 检验、Wilcoxon 符号秩检验和逻辑回归评估临床特征与 ELF3 表达之间的关系。Kaplan-Meier方法和Cox回归分析用于评估预后因素。基因集富集分析 (GSEA) 和免疫浸润分析用于评估 ELF3 在功能中的显着参与。
结果：OC 中的高 ELF3 表达与年龄相关（P<0.001）。高 ELF3 表达预测较差的总生存期 (OS) (HR: 1.37; 95% CI: 1.05-1.78; P=0.019) 和疾病特异性生存期 (DSS) (HR: 1.43; 95% CI: 1.08-1.89; P= 0.013)。并且 ELF3 表达（HR：1.779；95% CI：1.281-2.472；P<0.001）与 OC 患者的 OS 独立相关。GSEA 表明，包括 GPCR 配体结合、神经元系统、WNT 信号传导、翻译、神经活性配体-受体相互作用和 TCF 依赖性信号传导以响应 WNT 在内的途径在 ELF3 低表达表型中差异丰富。免疫浸润分析显示ELF3表达与免疫浸润相关。
结论：OC 患者中的 ELF3 表达与较差的生存率和免疫浸润显着相关，并且是 OC 中一个有希望的预后生物标志物。
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