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A Pan-Cancer Analysis of the Prognostic Value and Expression of Adenylate Cyclase 7 (ADCY7) in Human Tumors
International Journal of General Medicine ( IF 2.1 ) Pub Date : 2021-09-11 , DOI: 10.2147/ijgm.s330680 Yu Zeng 1 , Nanhong Li 2 , Zhenzhen Zheng 1 , Riken Chen 3 , Wang Liu 1 , Jinru Zhu 1 , Mingqing Zeng 4 , Junfen Cheng 1 , Min Peng 1 , Cheng Hong 3
International Journal of General Medicine ( IF 2.1 ) Pub Date : 2021-09-11 , DOI: 10.2147/ijgm.s330680 Yu Zeng 1 , Nanhong Li 2 , Zhenzhen Zheng 1 , Riken Chen 3 , Wang Liu 1 , Jinru Zhu 1 , Mingqing Zeng 4 , Junfen Cheng 1 , Min Peng 1 , Cheng Hong 3
Affiliation
Background: The role of adenylate cyclase 7 (ADCY7) in cancer is still unclear. This study analyzed the interrelationship between the expression and immune function of ADCY7.
Methods: ADCY7 expression in multiple human cancers was analyzed using the databases of Genotype-Tissue Expression Project (GTEx), Cancer Cell Line Encyclopedia (CCLE), and The Cancer Genome Atlas (TCGA). Correlations among ADCY7 gene expression, mismatch repair (MMR) gene expression, and DNA methyltransferase (DNMT) expression were assessed using Spearman correlation analysis. Univariate survival analysis and Kaplan–Meier (KM) curve were used to examine the effect of ADCY7 expression on prognosis. The Tumor Immune Estimation Resource (TIMER) database was used to evaluate the relationship between ADCY7 gene expression and tumor immune invasion or immune checkpoint gene (ICG) expression.
Results: ADCY7 was abnormally expressed in multiple human cancers and was correlated with MMR genes and DNMT expression. Univariate survival analysis and KM curve showed that ADCY7 expression influences the overall survival (OS) of six types of cancer, disease-specific survival (DSS) of eight, and progression-free interval (PFI) of three. The high expression of ADCY7 in OS, DSS, and PFI was strongly associated with poor outcomes in patients with breast cancer and lung squamous cell carcinoma. ADCY7 expression was strongly associated with immune cell infiltration and ICG expression.
Conclusion: The results of this study indicated that ADCY7 may be a prognostic biomarker of tumorigenesis. The study may also provide a new perspective on the role of ADCY7 in human cancers.
中文翻译：
人类肿瘤中腺苷酸环化酶 7 (ADCY7) 的预后价值和表达的泛癌症分析
背景：腺苷酸环化酶 7 (ADCY7) 在癌症中的作用仍不清楚。本研究分析了ADCY7的表达与免疫功能之间的相互关系。
方法：使用基因型组织表达计划 (GTEx)、癌细胞系百科全书 (CCLE) 和癌症基因组图谱 (TCGA) 的数据库分析多种人类癌症中的 ADCY7 表达。使用 Spearman 相关分析评估 ADCY7 基因表达、错配修复 (MMR) 基因表达和 DNA 甲基转移酶 (DNMT) 表达之间的相关性。采用单变量生存分析和Kaplan-Meier（KM）曲线来检查ADCY7表达对预后的影响。利用肿瘤免疫估计资源（TIMER）数据库评估ADCY7基因表达与肿瘤免疫侵袭或免疫检查点基因（ICG）表达之间的关系。
结果： ADCY7在多种人类癌症中异常表达，并与MMR基因和DNMT表达相关。单变量生存分析和 KM 曲线显示 ADCY7 表达影响 6 种癌症的总生存期 (OS)、8 种癌症的疾病特异性生存期 (DSS) 和 3 种癌症的无进展间期 (PFI)。ADCY7 在 OS、DSS 和 PFI 中的高表达与乳腺癌和肺鳞状细胞癌患者的不良预后密切相关。ADCY7 表达与免疫细胞浸润和 ICG 表达密切相关。
结论：本研究结果表明ADCY7可能是肿瘤发生的预后生物标志物。该研究还可能为 ADCY7 在人类癌症中的作用提供新的视角。
更新日期：2021-09-10
Methods: ADCY7 expression in multiple human cancers was analyzed using the databases of Genotype-Tissue Expression Project (GTEx), Cancer Cell Line Encyclopedia (CCLE), and The Cancer Genome Atlas (TCGA). Correlations among ADCY7 gene expression, mismatch repair (MMR) gene expression, and DNA methyltransferase (DNMT) expression were assessed using Spearman correlation analysis. Univariate survival analysis and Kaplan–Meier (KM) curve were used to examine the effect of ADCY7 expression on prognosis. The Tumor Immune Estimation Resource (TIMER) database was used to evaluate the relationship between ADCY7 gene expression and tumor immune invasion or immune checkpoint gene (ICG) expression.
Results: ADCY7 was abnormally expressed in multiple human cancers and was correlated with MMR genes and DNMT expression. Univariate survival analysis and KM curve showed that ADCY7 expression influences the overall survival (OS) of six types of cancer, disease-specific survival (DSS) of eight, and progression-free interval (PFI) of three. The high expression of ADCY7 in OS, DSS, and PFI was strongly associated with poor outcomes in patients with breast cancer and lung squamous cell carcinoma. ADCY7 expression was strongly associated with immune cell infiltration and ICG expression.
Conclusion: The results of this study indicated that ADCY7 may be a prognostic biomarker of tumorigenesis. The study may also provide a new perspective on the role of ADCY7 in human cancers.
中文翻译：
人类肿瘤中腺苷酸环化酶 7 (ADCY7) 的预后价值和表达的泛癌症分析
背景：腺苷酸环化酶 7 (ADCY7) 在癌症中的作用仍不清楚。本研究分析了ADCY7的表达与免疫功能之间的相互关系。
方法：使用基因型组织表达计划 (GTEx)、癌细胞系百科全书 (CCLE) 和癌症基因组图谱 (TCGA) 的数据库分析多种人类癌症中的 ADCY7 表达。使用 Spearman 相关分析评估 ADCY7 基因表达、错配修复 (MMR) 基因表达和 DNA 甲基转移酶 (DNMT) 表达之间的相关性。采用单变量生存分析和Kaplan-Meier（KM）曲线来检查ADCY7表达对预后的影响。利用肿瘤免疫估计资源（TIMER）数据库评估ADCY7基因表达与肿瘤免疫侵袭或免疫检查点基因（ICG）表达之间的关系。
结果： ADCY7在多种人类癌症中异常表达，并与MMR基因和DNMT表达相关。单变量生存分析和 KM 曲线显示 ADCY7 表达影响 6 种癌症的总生存期 (OS)、8 种癌症的疾病特异性生存期 (DSS) 和 3 种癌症的无进展间期 (PFI)。ADCY7 在 OS、DSS 和 PFI 中的高表达与乳腺癌和肺鳞状细胞癌患者的不良预后密切相关。ADCY7 表达与免疫细胞浸润和 ICG 表达密切相关。
结论：本研究结果表明ADCY7可能是肿瘤发生的预后生物标志物。该研究还可能为 ADCY7 在人类癌症中的作用提供新的视角。
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