NOD/scid IL-2Rγnull mice reconstituted with peripheral blood mononuclear cells from patients with Crohn's disease reflect the human pathological phenotype,Immunity, Inflammation and Disease

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NOD/scid IL-2Rγnull mice reconstituted with peripheral blood mononuclear cells from patients with Crohn's disease reflect the human pathological phenotype
Immunity, Inflammation and Disease ( IF 3.1 ) Pub Date : 2021-09-09 , DOI: 10.1002/iid3.516
Anna-Lena Unterweger ₁ , Alena Rüscher ₁ , Marietta Seuß ₁ , Paula Winkelmann ₁ , Florian Beigel ₂ , Leandra Koletzko ₂ , Simone Breiteneicher ₂ , Matthias Siebeck ₁ , Roswitha Gropp ₁ , Attila Aszodi ₃

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Crohn's disease (CD) is characterized by pronounced intestinal fibrosis and severe mucosal damage and conventional animal models are limited to reflect these pathological manifestations. The aim of this study was to examine whether the combination of patient immune-profiling and preclinical studies in a mouse model based on NOD/scid IL-2Rγ^null (NSG) reconstituted with peripheral blood mononuclear cells (PBMC) from CD patients has the capacity to harmonize ex vivo human and in vivo animal studies.

中文翻译：

用克罗恩病患者的外周血单核细胞重建的 NOD/scid IL-2Rγnull 小鼠反映了人类病理表型

克罗恩病 (CD) 的特点是明显的肠道纤维化和严重的粘膜损伤，常规动物模型仅限于反映这些病理表现。本研究的目的是检查在基于 NOD/scid IL-2Rγ ^null (NSG)的小鼠模型中进行患者免疫分析和临床前研究的组合，该小鼠模型由 CD 患者的外周血单核细胞 (PBMC) 重建而成协调体外人类和体内动物研究。

更新日期：2021-11-13

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