Because of their renewability and environmental friendliness, the synthesis of nanomaterials with low environmental risk and unique functional features via plant extracts has recently attracted researchers' interest around the world. We synthesized Fe nanoparticles (Fe NPs) from Clove and Green Coffee (G-Coffee) extracts and examined them using a variety of techniques in this study. The hepatoprotective activity of the Fe NPs using Clove or G-Coffee nanoplatform in paracetamol (PCM) in Wistar albino rats was investigated. Simultaneous administration of the Fe NPs from clove or green coffee with PCM significantly attenuated the side changes in the serum, total albumin (TP), Alanine aminotransferase (ALT), Aspartate Alanine aminotransferase (AST), and Alkaline phosphatase (ALP). The liver histopathological examination showed a notable decrease in liver toxicity, and liver tissue was sustained at almost the normal level. The toxicity of the Fe NPs was investigated. The results confirmed that the Fe NPs synthesized from both extracts are potent hepatoprotective agents against PCM-induced hepatotoxicity in rats.

由于其可再生性和环境友好性，通过植物提取物合成具有低环境风险和独特功能特征的纳米材料最近引起了世界各地研究人员的兴趣。我们从丁香和绿咖啡 (G-Coffee) 提取物中合成了 Fe 纳米粒子 (Fe NPs)，并在本研究中使用各种技术对其进行了检查。研究了使用丁香或 G-咖啡纳米平台在对乙酰氨基酚 (PCM) 中的 Fe NPs 在 Wistar 白化大鼠中的保肝活性。同时施用来自丁香或生咖啡的 Fe NPs 与 PCM 显着减弱了血清、总白蛋白 (TP)、丙氨酸氨基转移酶 (ALT)、天冬氨酸丙氨酸氨基转移酶 (AST) 和碱性磷酸酶 (ALP) 的副作用。肝脏组织病理学检查显示肝毒性显着降低，肝组织维持在几乎正常水平。研究了 Fe NPs 的毒性。结果证实，由两种提取物合成的 Fe NPs 是有效的肝脏保护剂，可对抗 PCM 诱导的大鼠肝毒性。