Impact of fractional amplitude of low-frequency fluctuations in motor- and sensory-related brain networks on spinal cord injury severity,NMR in Biomedicine

当前位置： X-MOL 学术 › NMR Biomed. › 论文详情

Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)

Impact of fractional amplitude of low-frequency fluctuations in motor- and sensory-related brain networks on spinal cord injury severity
NMR in Biomedicine ( IF 2.7 ) Pub Date : 2021-09-10 , DOI: 10.1002/nbm.4612
Ae Ryoung Kim _{1,

2} , Hyunsil Cha ₃ , Eunji Kim ₃ , Seungho Kim ₃ , Hui Joong Lee _{4,

5} , Eunhee Park _{1,

2} , Yang-Soo Lee _{1,

2} , Tae-Du Jung _{1,

2} , Yongmin Chang _{3,

5,

6}

Affiliation

Spinal cord injury (SCI) can cause motor, sensory, and autonomic dysfunctions and may affect the cerebral functions. However, the mechanisms of plastic changes in the brain according to SCI severity remain poorly understood. Therefore, in the current study, we compared the brain activity of the entire neural network according to severity of SCI using fractional amplitude of low-frequency fluctuations (fALFF) analysis in resting-state functional magnetic resonance imaging (rs-fMRI). A total of 59 participants were included, consisting of 19 patients with complete SCI, 20 patients with incomplete SCI, and 20 healthy individuals. Their motor and sensory functions were evaluated. The rs-fMRI data of low-frequency fluctuations were analyzed based on fALFF. Differences in fALFF values among complete-SCI patients, incomplete-SCI patients, and healthy controls were assessed using ANOVA. Then post hoc analysis and two-sample t-tests were conducted to assess the differences between the three groups. Pearson correlation analyses were used to determine correlations between clinical measures and the z-score of the fALFF in the SCI groups. Patients with SCI (complete and incomplete) showed lower fALFF values in the superior medial frontal gyrus than the healthy controls, and were associated with poor motor and sensory function (p < .05). Higher fALFF values were observed in the putamen and thalamus, and were negatively associated with motor and sensory function (p < .05). In conclusion, alterations in the neural activity of the motor- and sensory-related networks of the brain were observed in complete-SCI and incomplete-SCI patients. Moreover, plastic changes in these brain regions were associated with motor and sensory function.

中文翻译：

运动和感觉相关脑网络中低频波动的分数幅度对脊髓损伤严重程度的影响

脊髓损伤 (SCI) 可导致运动、感觉和自主神经功能障碍，并可能影响大脑功能。然而，根据 SCI 严重程度，大脑中塑性变化的机制仍然知之甚少。因此，在目前的研究中，我们使用静息状态功能磁共振成像 (rs-fMRI) 中低频波动的分数振幅 (fALFF) 分析根据 SCI 的严重程度比较了整个神经网络的大脑活动。共纳入 59 名参与者，包括 19 名完全 SCI 患者、20 名不完全 SCI 患者和 20 名健康人。评估了他们的运动和感觉功能。基于fALFF分析低频波动的rs-fMRI数据。完全 SCI 患者、不完全 SCI 患者中 fALFF 值的差异，使用方差分析评估健康对照。然后进行事后分析和两样本t检验以评估三组之间的差异。Pearson 相关分析用于确定临床测量与 SCI 组中 fALFF 的 z 分数之间的相关性。SCI 患者（完全和不完全）在额内侧上回的 fALFF 值低于健康对照组，并且与运动和感觉功能差有关。p < .05)。在壳核和丘脑中观察到较高的 fALFF 值，并且与运动和感觉功能呈负相关 ( p < .05)。总之，在完全 SCI 和不完全 SCI 患者中观察到大脑运动和感觉相关网络的神经活动的改变。此外，这些大脑区域的塑性变化与运动和感觉功能有关。

更新日期：2021-09-10

点击分享查看原文

点击收藏

阅读更多本刊最新论文本刊介绍/投稿指南11