Background

It remains under-investigated whether prostatic lipid profiles are associated with pathogenesis, progression, racial disparity, and discovery of biomarkers in prostate cancer (PCa).

Methods

The electrospray ionization-tandem mass spectrometry was applied to quantitate prostatic lipids in human and mouse PCa and non-cancer prostatic tissues. Biostatistics and bioinformatics were used to compare the concentrations of prostatic lipids at levels of total lipid, group, class and individual species between PCa and benign prostatic tissues, between races, and among pathological conditions of PCa.

Results

Prostatic concentrations of total lipids as well as neutral lipids were significantly higher in PCa than in benign prostatic tissues in all population and Caucasian American population, but not in African American population. The prostatic phospholipid were not statistically different between PCa and benign prostatic tissues in all study populations. Cholesteryl ester is the only lipid class significantly higher in PCa than in benign prostatic tissues in all study populations. A panel of prostatic lipid parameters in each study population was identified as diagnostic and prognostic biomarkers with >60% of sensitivity, specificity and accuracy simultaneously. Lipid profiling on mouse prostatic tissues further confirmed correlation of prostatic lipid profiles to the pathogenesis and progression of PCa. In addition, a few prostatic lipids in mouse can serve as prognostic biomarkers in differentiation of indolent from aggressive PCa.

Conclusion

The prostatic lipids are widely associated with the pathogenesis, progression and racial disparity of PCa. A panel of prostatic lipids can serve as diagnostic, prognostic and race-specific biomarkers for PCa.

中文翻译：

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前列腺脂质与进展、种族差异和前列腺癌生物标志物发现的关联

背景

前列腺血脂谱是否与前列腺癌 (PCa) 的发病机制、进展、种族差异和生物标志物的发现有关，尚待研究。

方法

电喷雾电离串联质谱法用于定量人和小鼠 PCa 和非癌前列腺组织中的前列腺脂质。使用生物统计学和生物信息学来比较 PCa 和良性前列腺组织之间、种族之间以及 PCa 病理状况之间的总脂质、组、类别和个体物种水平下的前列腺脂质浓度。

结果

在所有人群和白种美国人人群中，PCa 中总脂质和中性脂质的前列腺浓度显着高于良性前列腺组织，但在非裔美国人人群中则不然。在所有研究人群中，前列腺磷脂在 PCa 和良性前列腺组织之间没有统计学差异。在所有研究人群中，胆固醇酯是唯一一种在 PCa 中明显高于良性前列腺组织的脂质类别。每个研究人群中的一组前列腺脂质参数被确定为诊断和预后生物标志物，同时具有 >60% 的敏感性、特异性和准确性。小鼠前列腺组织的脂质谱进一步证实了前列腺脂质谱与 PCa 的发病机制和进展的相关性。此外，

结论

前列腺脂质与 PCa 的发病机制、进展和种族差异广泛相关。一组前列腺脂质可作为 PCa 的诊断、预后和种族特异性生物标志物。