In recent years, neuroimaging evidence shows that the brains of Parkinson disease (PD) with impulse control disorders (ICDs) patients have functional disconnection changes. However, so far, it is still unclear whether the topological organization is damaged in PD patients with ICD. In this study, we aimed to explore the functional brain network in 18 patients with PD with ICDs (PD-ICD) and 18 patients with PD without ICDs (PD-nICD) by using functional magnetic resonance imaging and graph theory approach. We found that the PD-ICD patients had increased clustering coefficient and characteristic path length, while decreased small-world index compared with PD-nICD patients. Furthermore, we explored the hypothesis whether the abnormality of the small-world network parameters of PD-ICD patients is accompanied by the change of nodal centrality. As we hypothesized, the nodal centralities of the default mode network, control network, and dorsal attention network were found to be significantly damaged in the PD-ICD group compared with the PD-nICD group. Our study provides more evidence for PD-ICD patients' brain network abnormalities from the perspective of information exchange, which may be the underlying pathophysiological basis of brain abnormalities in PD-ICD patients.

中文翻译：

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帕金森病伴脉冲控制障碍的异常拓扑网络：静息态功能磁共振成像研究。

近年来，神经影像学证据表明，帕金森病（PD）合并冲动控制障碍（ICD）患者的大脑存在功能性断开改变。然而，迄今为止，尚不清楚植入ICD的PD患者的拓扑组织是否受损。在本研究中，我们旨在通过功能磁共振成像和图论方法探讨 18 例带有 ICD 的 PD 患者 (PD-ICD) 和 18 例不带 ICD 的 PD 患者 (PD-nICD) 的功能性大脑网络。我们发现与PD-nICD患者相比，PD-ICD患者的聚类系数和特征路径长度增加，而小世界指数降低。此外，我们还探讨了PD-ICD患者小世界网络参数异常是否伴随节点中心性变化的假设。正如我们假设的，与 PD-nICD 组相比，PD-ICD 组的默认模式网络、控制网络和背侧注意网络的节点中心性明显受损。我们的研究从信息交换的角度为PD-ICD患者脑网络异常提供了更多证据，这可能是PD-ICD患者脑部异常的潜在病理生理基础。