In the era of randomized controlled trials and multicenter observational studies, it is easy for academic neurology to overlook the compelling questions posed by individual patient cases. Sporadic Creutzfeldt-Jakob disease (sCJD) in a 21-year-old patient was the right diagnosis, but hardly a satisfactory explanation for either the doctor or patient and his family in the Clinical/Scientific Note by Appleby et al.¹ in this week's issue of Neurology®. How can a typically late-onset disorder occur in someone so young?

中文翻译：

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非常年轻的散发性克雅氏病的棘手难题

在随机对照试验和多中心观察研究的时代，学术神经学很容易忽视个别患者病例提出的令人信服的问题。一名 21 岁患者的散发性克雅氏病 (sCJD) 是正确的诊断，但在 Appleby 等人的《临床/科学说明》中，对于医生或患者及其家人来说，这很难令人满意的解释。¹在本周一期的Neurology®中。这么年轻的人怎么会出现典型的迟发性疾病？