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DREAM On: Cell Cycle Control in Development and Disease
Annual Review of Genetics ( IF 8.7 ) Pub Date : 2021-11-23 , DOI: 10.1146/annurev-genet-071819-103836
Hayley Walston 1 , Audra N Iness 2 , Larisa Litovchick 1, 3, 4
Affiliation  

Perfectly orchestrated periodic gene expression during cell cycle progression is essential for maintaining genome integrity and ensuring that cell proliferation can be stopped by environmental signals. Genetic and proteomic studies during the past two decades revealed remarkable evolutionary conservation of the key mechanisms that control cell cycle–regulated gene expression, including multisubunit DNA-binding DREAM complexes. DREAM complexes containing a retinoblastoma family member, an E2F transcription factor and its dimerization partner, and five proteins related to products of Caenorhabditis elegans multivulva (Muv) class B genes lin-9, lin-37, lin-52, lin-53, and lin-54 (comprising the MuvB core) have been described in diverse organisms, from worms to humans. This review summarizes the current knowledge of the structure, function, and regulation of DREAM complexes in different organisms, as well as the role of DREAM in human disease.

中文翻译:


DREAM On:发育和疾病中的细胞周期控制

在细胞周期进程中完美协调的周期性基因表达对于维持基因组完整性和确保细胞增殖可以被环境信号停止至关重要。过去二十年的遗传和蛋白质组学研究揭示了控制细胞周期调节基因表达的关键机制的显着进化保守性,包括多亚基 DNA 结合 DREAM 复合物。DREAM 复合物包含一个视网膜母细胞瘤家族成员、一个 E2F 转录因子及其二聚化伙伴,以及与多外阴秀丽隐杆线虫(Muv) B 类基因lin-9lin-37lin-52lin-53lin-54(包括 MuvB 核心)已在从蠕虫到人类的多种生物体中进行了描述。本综述总结了目前对不同生物体中 DREAM 复合物的结构、功能和调控的认识,以及 DREAM 在人类疾病中的作用。

更新日期:2021-11-24
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