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Behavioral Induction of a High Beta State in Sensorimotor Cortex Leads to Movement Slowing.
Journal of Cognitive Neuroscience ( IF 3.2 ) Pub Date : 2021-06-01 , DOI: 10.1162/jocn_a_01717
Vignesh Muralidharan 1 , Adam R Aron 1
Affiliation  

The sensorimotor beta rhythm (∼13-30 Hz) is commonly seen in relation to movement. It is important to understand its functional/behavioral significance in both health and disease. Sorting out competing theories of sensorimotor beta is hampered by a paucity of experimental protocols in humans that manipulate/induce beta oscillations and test their putative effects on concurrent behavior. Here, we developed a novel behavioral paradigm to generate beta and then test its functional relevance. In two human experiments with scalp EEG (n = 11 and 15), we show that a movement instruction generates a high beta state (postmovement beta rebound), which then slows down subsequent movements required during that state. We also show that this high initial beta rebound related to reduced mu-beta desynchronization for the subsequent movement and, further, that the temporal features of the beta state, that is, the beta bursts, related to the degree of slowing. These results suggest that increased sensorimotor beta in the postmovement period corresponds to an inhibitory state-insofar as it retards subsequent movement. By demonstrating a behavioral method by which people can proactively create a high beta state, our paradigm provides opportunities to test the effect of this state on sensations and affordances. It also suggests related experiments using motor imagery rather than actual movement, and this could later be clinically relevant, for example, in tic disorder.

中文翻译:

感觉运动皮层中高 Beta 状态的行为诱导导致运动减慢。

感觉运动β节律(~13-30 Hz)通常与运动有关。了解其在健康和疾病中的功能/行为意义非常重要。由于人类缺乏操纵/诱导 β 振荡并测试它们对并发行为的推定影响的实验协议,整理出相互竞争的感觉运动 β 理论受到阻碍。在这里,我们开发了一种新的行为范式来生成 beta,然后测试其功能相关性。在头皮脑电图(n = 11 和 15)的两项人体实验中,我们表明运动指令会产生高 beta 状态(运动后 beta 反弹),然后减慢该状态下所需的后续运动。我们还表明,这种高初始 beta 反弹与后续运动的 mu-beta 去同步减少有关,此外,即β状态的时间特征,即β爆发,与减速的程度有关。这些结果表明,在运动后时期增加的感觉运动β对应于抑制状态,因为它延缓了随后的运动。通过展示人们可以主动创建高贝塔状态的行为方法,我们的范式提供了测试这种状态对感觉和可供性的影响的机会。它还建议使用运动图像而不是实际运动进行相关实验,这可能在以后具有临床相关性,例如抽动障碍。这些结果表明,在运动后时期增加的感觉运动β对应于抑制状态,因为它延缓了随后的运动。通过展示人们可以主动创建高贝塔状态的行为方法,我们的范式提供了测试这种状态对感觉和可供性的影响的机会。它还建议使用运动图像而不是实际运动进行相关实验,这可能在以后具有临床相关性,例如抽动障碍。这些结果表明,在运动后时期增加的感觉运动β对应于抑制状态,因为它延缓了随后的运动。通过展示人们可以主动创建高贝塔状态的行为方法,我们的范式提供了测试这种状态对感觉和可供性的影响的机会。它还建议使用运动图像而不是实际运动进行相关实验,这可能在以后具有临床相关性,例如抽动障碍。
更新日期:2021-06-01
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