Abstract

Acute myeloid leukemia (AML) is a highly malignant blood cancer disease, with dismal prognosis. The theory that cancer cells utilize metabolism to their growth advantage was postulated almost hundred years ago. However, only recently have been able to take advantage of this Achilles heel of malignant cell growth. Current observations suggest a crucial role for various metabolic pathways in AML, and special in leukemia stem cells, believed to be responsible for re-initiation of the leukemic clone, and hence relapse of this devastating disease. In the present article we discuss the features for metabolism in AML based on recent research, and special emphasizing the potential of pharmacological inhibiting metabolism as new treatment approaches.

摘要

急性髓系白血病（AML）是一种恶性程度很高的血液肿瘤疾病，预后不佳。癌细胞利用新陈代谢来促进其生长的理论几乎在一百年前就被提出了。然而，直到最近才能够利用恶性细胞生长的这个致命弱点。目前的观察表明，各种代谢途径在 AML 中的关键作用，特别是在白血病干细胞中，被认为是导致白血病克隆的重新启动，从而导致这种破坏性疾病复发的原因。在本文中，我们根据最近的研究讨论了 AML 代谢的特征，并特别强调了药物抑制代谢作为新治疗方法的潜力。